Imidazoquinoline derivatives (IMDs) and related compounds function as synthetic agonists
of Toll-like receptors 7 and 8 (TLR7/8) and one is FDA approved for topical antiviral and skin …

Since first being described in the fruit fly Drosophila melanogaster, Toll-like receptors (TLRs)
have proven to be of great interest to immunologists and investigators interested in the …

The Toll-like receptors (TLRs) 7 and 8 play an important role in the immune system
activation, and their agonists may therefore serve as promising candidate vaccine adjuvants …

Toll-like receptors (TLRs) are the pattern recognition receptors (PRRs) that recognize
pathogen-associated molecular patterns (PAMPs) in microbial species. Among the various …

The immune response plays a pivotal role in the pathogenesis of diseases. Toll-like receptor
4 (TLR4), as an intrinsic immune receptor, exhibits widespread in vivo expression and its …

Toll‐Like Receptors (TLRs) are the innate immunity receptors that play an activating role
when interacting with molecules released by bacteria and viruses (PAMPs, pathogen …

Toll-like receptor (TLR) agonists activate both the innate and the adaptive immune systems.
These TLR agonists have been exploited as potent vaccine adjuvants and antitumor agents …

Oligodeoxyribonucleotides containing unmethylated CpG motifs act as TLR9 agonists. In
this study, we evaluated oligonucleotides containing an unmethylated CpG motif in which …

Toll-like receptor 7 (TLR7) is an established therapeutic target in myriad autoimmune
disorders, but no TLR7 antagonist is available for clinical use to date. Herein, we report a …

Toll-like receptor 4 (TLR4) is involved in activation of the innate immune response in a large
number of different diseases. Despite numerous studies, the role of separate domains of …