Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis

A Günther, M Korfei, P Mahavadi… - European …, 2012 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition, with a median survival of<
3 yrs. The pathophysiology is not fully understood, but chronic injury of alveolar epithelial …

Strategies for treating idiopathic pulmonary fibrosis

RM Du Bois - Nature reviews Drug discovery, 2010 - nature.com
Idiopathic pulmonary fibrosis (IPF) is the most common and most lethal diffuse fibrosing lung
disease, with a mortality rate that exceeds that of many cancers. Recently, there have been …

Antifibrotic therapy for fibrotic lung disease beyond idiopathic pulmonary fibrosis

BF Collins, G Raghu - European Respiratory Review, 2019 - Eur Respiratory Soc
Two antifibrotic medications (nintedanib and pirfenidone) were recommended
(conditionally) for the treatment of patients with idiopathic pulmonary fibrosis (IPF) in the …

Pharmacological treatment of idiopathic pulmonary fibrosis: an update

P Spagnolo, AU Wells, HR Collard - Drug Discovery Today, 2015 - Elsevier
Highlights•Idiopathic pulmonary fibrosis (IPF) is a progressive disease with no cure.•A
number of clinical trials of potential treatments have recently been completed.•Pirfenidone …

Progress in understanding and treating idiopathic pulmonary fibrosis

JA Kropski, TS Blackwell - Annual review of medicine, 2019 - annualreviews.org
This is a time of substantial progress in the evaluation and care of patients with idiopathic
pulmonary fibrosis (IPF). In addition to the approval and widespread availability of the first …

Pirfenidone: antifibrotic agent for idiopathic pulmonary fibrosis

A Azuma - Expert review of respiratory medicine, 2010 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a devastating disease with rare incidence but high
mortality, and the pathogenesis of which is still poorly understood. Available treatment …

Reviews and prospectives of signaling pathway analysis in idiopathic pulmonary fibrosis

Z Yan, Z Ping - Autoimmunity reviews, 2014 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing disease with disappointing
survival rate, and uneffective therapeutic progress has been made in the last few years …

[HTML][HTML] Idiopathic pulmonary fibrosis

EB Meltzer, PW Noble - Orphanet journal of rare diseases, 2008 - Springer
Idiopathic pulmonary fibrosis (IPF) is a non-neoplastic pulmonary disease that is
characterized by the formation of scar tissue within the lungs in the absence of any known …

Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group

RG Crystal, PB Bitterman, B Mossman… - American journal of …, 2002 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is an insidious inflammatory fibroproliferative disease
whose cause and course before diagnosis are unknown, and for which existing treatments …

Molecular pathways and role of epigenetics in the idiopathic pulmonary fibrosis

V Velagacherla, CH Mehta, Y Nayak, UY Nayak - Life Sciences, 2022 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with unknown etiological factors
that can progress to other dangerous diseases like lung cancer. Environmental and genetic …