Diabetic kidney disease (DKD) is a common microvascular complication of diabetes
mellitus, and oxidative stress and mitochondrial dysfunction play an important role in this …

The aim of this study was to investigate the effect and possible mechanism of Astragaloside
IV (AS-IV) on retarding the progression of diabetic nephropathy (DN) in a type 2 diabetic …

Astragaloside II (AS II), a novel saponin purified from Astragalus membranes, has been
reported to modulate the immune response, repair tissue injury, and prevent inflammatory …

Defective antioxidant system as well as mitochondrial dysfunction contributes to the
pathogenesis and progression of diabetic kidney disease (DKD). Nuclear factor erythroid 2 …

Introduction: Chronic kidney disease (CKD) can lead to significant elevation of 1-
deoxysphingolipids (1-deoxySL). The increase of 1-deoxySL in turn can result in …

Background Mitochondrial dynamics plays a crucial role in tubular injury in diabetic kidney
disease (DKD). Asiatic acid (AA) has demonstrated renal protective effects in DKD; however …

Many patients with type 1 diabetes mellitus suffer from progressive diabetic kidney disease
(DKD). The progression of DKD is largely attributed to mitochondrial dysfunction, with key …

Background Mitochondrial dysfunction is considered to be an important contributor in
podocyte injury under diabetic conditions. The BaoShenTongLuo (BSTL) formula has been …

Background Salidroside, an active component from Traditional Chinese Medicine Rhodiola
rosea L., has various pharmacological functions including anti-inflammatory, anti-cancer and …

Abstract Astragaloside IV (AS-IV) exhibits diverse biological activities. Despite this, the
detailed molecular mechanisms by which AS-IV ameliorates diabetic nephropathy (DN) and …