Background Gastric cancer (GC) is one of the most common causes of cancer death.
Hypoxia is an important property of the tumor microenvironment of GC. Increasing evidence …

Cancer-associated fibroblasts (CAFs) have been considered to play an important role for
tumor progression of cancer. Solid tumors contain heterogeneous distribution of oxygen in …

Cancer stem cells (CSCs), a subpopulation possess tumor initiation and self-renewal
capacity, are responsible for recurrence, metastases and drug resistance. Thus, it is …

INTRODUCTION: Pancreatic cancer is characterized by extraordinary fibrosis and
pancreatic stellate cells (PSCs) are the major player in synthesizing extracellular matrix …

Pancreatic cancer is one of the leading causes of death worldwide among all cancer types
due to difficulty detecting in early-stages of disease. Poor understanding of the mediators …

Pancreatic adenocarcinoma (PDAC) is a cancer particularly resistant to current therapies.
One possible reason consists in its cellular composition that limits access to drugs. Indeed …

Cancer stem cells (CSCs) which are known to be residing deep inside the core of the tumor
in its hypoxia niche is responsible for relapse of cancers. Owing to this hypoxic niche, the …

Stromal cells are one of the important components of tumor mieroenvironment, which plays
an oncogenic role in tumorigenesis. Stromai cells and their products can transform adjacent …

Hypoxia caused by rapid growth of cancer cells and insufficient central blood supply is one
of the characteristics of tumor microenvironment, especially in pancreatic cancer. An …

Chronic inflammation has a crucial role in cancer development and the progression of
various tumors, including pancreatic ductal adenocarcinoma (PDAC). The arachidonate …