Uneven oxygen supply in solid tumors leads to hypoxic and normoxic regions. Hypoxic cells
exhibit increased secretion of lactate, which creates an acidic tumor microenvironment …

The role of tumor interaction with stromal components during carcinogenesis is crucial for
the design of efficient cancer treatment approaches. It is widely admitted that tumor hypoxic …

28 Role of Microenvironment in Regulating Stem Cell and Tumor Initiating Cancer Cell Behavior
and Its Potential Therapeutic Page 317 28 Role of Microenvironment in Regulating Stem Cell and …

A lot of effort has been done to study how cancer cells react to low-oxygen tension, a
condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor …

Hypoxia microenvironment, as a major feature of solid tumors, increases tumors progression
and metastasis. To research whether hypoxia influences the epithelial–mesenchymal …

Tumour-stroma interaction plays a significant role for malignant growth. Here, we analyzed
the functional and molecular sequels of interaction in a non-contact co-culture model …

Recent observations on the conversion of fibroblasts to induced pluripotent stem (iPS) cells
suggest that non stem cells may be converted to stem cells, and thereby acquire tumorigenic …

Pancreatic cancer is characterized by a hypoxic tumor microenvironment, which is primarily
caused by massive fibrosis with pancreatic stellate cells (PSCs) as a main component. Our …

Mass cytometry imaging is a novel technique that allows sub-cellular resolution
measurements of the abundance of dozen proteins directly in tissues (Giesen et al.,“Highly …

The tumour-microenvironment consists of malignant epithelial cells, surrounding cancer
associated (myo-) fibroblasts, endothelial cells creating the tumours__ vasculature system …