Innate Immunity Holding the Flanks until Reinforced by Adaptive Immunity against Mycobacterium tuberculosis Infection

N Khan, A Vidyarthi, S Javed, JN Agrewala - Frontiers in microbiology, 2016 - frontiersin.org
T cells play a cardinal role in imparting protection against Mycobacterium tuberculosis (Mtb).
However, ample time is required before T-cells are able to evoke efficient effector responses …

Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis

P Sankar, BB Mishra - Frontiers in Immunology, 2023 - frontiersin.org
Tuberculosis (TB) remains a significant global health challenge, claiming the lives of up to
1.5 million individuals annually. TB is caused by the human pathogen Mycobacterium …

Innate immunity in tuberculosis: host defense vs pathogen evasion

CH Liu, H Liu, B Ge - Cellular & molecular immunology, 2017 - nature.com
The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Innate Immune Defenses in Human Tuberculosis: An Overview of the Interactions between Mycobacterium tuberculosis and Innate Immune Cells

JK Sia, M Georgieva… - Journal of immunology …, 2015 - Wiley Online Library
Tuberculosis (TB) remains a serious global public health problem that results in up to 2
million deaths each year. TB is caused by the human pathogen, Mycobacterium tuberculosis …

Mycobacterial dormancy systems and host responses in tuberculosis

V Peddireddy, SN Doddam, N Ahmed - Frontiers in immunology, 2017 - frontiersin.org
Tuberculosis (TB) caused by the intracellular pathogen, Mycobacterium tuberculosis (Mtb),
claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged …

Immunological Protection Against Mycobacterium tuberculosis Infection

Y Yoshikai - Critical Reviews™ in Immunology, 2006 - dl.begellhouse.com
Mycobacterium tuberculosis (Mtb) invades the lung via an airborne pathway, and the
bacteria reach the lung alveoli and are then engulfed by alveolar macrophages in innate …

New insights into the evasion of host innate immunity by Mycobacterium tuberculosis

Q Chai, L Wang, CH Liu, B Ge - Cellular & molecular immunology, 2020 - nature.com
Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that
causes tuberculosis (TB), which remains the leading infectious cause of human death. The …

Host defense mechanisms against Mycobacterium tuberculosis

Q Chai, Z Lu, CH Liu - Cellular and Molecular Life Sciences, 2020 - Springer
Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), remains the
leading cause of death worldwide from a single infectious pathogen. Mtb is a paradigmatic …

Understanding delayed T‐cell priming, lung recruitment, and airway luminal T‐cell responses in host defense against pulmonary tuberculosis

CR Shaler, C Horvath, R Lai… - Journal of Immunology …, 2012 - Wiley Online Library
Mycobacterium tuberculosis (M. tb), the causative bacterium of pulmonary tuberculosis (TB),
is a serious global health concern. Central to M. tb effective immune avoidance is its ability …

Striking the right immunological balance prevents progression of tuberculosis

SP Vyas, R Goswami - Inflammation Research, 2017 - Springer
Introduction Tuberculosis (TB) caused by infection with Mycobacterium tuberculosis (Mtb) is
a major burden for human health worldwide. Current standard treatments for TB require …