Abstract Interleukin 23 (IL-23) is required for autoimmune inflammation mediated by IL-17-
producing helper T cells (TH-17 cells) and has been linked to many human immune …

CD4+ T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although
the precise mechanisms that control their development are undefined. Here we present data …

T helper cells that produce interleukin 17 (IL-17;'TH-17 cells') are a distinct subset of
proinflammatory cells whose in vivo function requires IL-23 but whose in vitro differentiation …

Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong
structural relationship that includes a shared p40 subunit, this does not translate into …

Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a
common p40 subunit shared with IL-12. IL-12 is important for the development of T helper …

Studies have shown that transforming growth factor-β (TGF-β) and interleukin 6 (IL-6) are
required for the lineage commitment of pathogenic IL-17-producing T helper cells (TH-17 …

TH-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for
autoimmune disease. In mice, commitment to the TH-17 lineage is dependent on …

Abstract Interleukin 17 (IL-17) has been linked to autoimmune diseases, although its
regulation and function have remained unclear. Here we have evaluated in vitro and in vivo …

Understanding the factors that influence T helper 1 (TH1)-and TH2-cell responses has been
one of the main focuses of immunology for almost 20 years. Whereas the central role of …

Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells.
Despite increasing evidence that high levels of IL-17 are associated with several chronic …