The role of cytokines in the pathogenesis of rheumatoid arthritis–Practical and potential application of cytokines as biomarkers and targets of personalized therapy

E Brzustewicz, E Bryl - Cytokine, 2015 - Elsevier
Rheumatoid arthritis (RA), as a common chronic disease leading to severe disability,
requires early diagnosis and introduction of proper treatment. Deregulation in the cytokine …

Cytokines in the pathogenesis of rheumatoid arthritis: new players and therapeutic targets

A Alunno, F Carubbi, R Giacomelli, R Gerli - BMC rheumatology, 2017 - Springer
In recent years, the landscape of pro-and anti-inflammatory cytokines has rapidly expanded
with the identification of new members proven to be involved at different extent in the …

Cytokines as biomarkers in rheumatoid arthritis

A Burska, M Boissinot, F Ponchel - Mediators of inflammation, 2014 - Wiley Online Library
RA is a complex disease that develops as a series of events often referred to as disease
continuum. RA would benefit from novel biomarker development for diagnosis where new …

Selected cytokine pathways in rheumatoid arthritis

M Noack, P Miossec - Seminars in immunopathology, 2017 - Springer
Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction.
Cytokines play a key role in its pathogenesis. They contribute to the induction and …

Cytokines in rheumatoid arthritis—shaping the immunological landscape

IB McInnes, CD Buckley, JD Isaacs - Nature Reviews Rheumatology, 2016 - nature.com
Cytokine-mediated pathways are central to the pathogenesis of rheumatoid arthritis (RA).
The purpose of this short Opinion article is to briefly overview the roles of cytokine families in …

Cytokines in the pathogenesis of rheumatoid arthritis

IB McInnes, G Schett - Nature Reviews Immunology, 2007 - nature.com
Cytokines regulate a broad range of inflammatory processes that are implicated in the
pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well known that an imbalance …

Cytokines as therapeutic targets in rheumatoid arthritis and other inflammatory diseases

S Siebert, A Tsoukas, J Robertson, I McInnes - Pharmacological reviews, 2015 - ASPET
The human immune system involves highly complex and coordinated processes in which
small proteins named cytokines play a key role. Cytokines have been implicated in the …

Cytokines in rheumatoid arthritis: potential targets for pharmacological intervention

Z Szekanecz, AE Koch, SL Kunkel, RM Strieter - Drugs & aging, 1998 - Springer
The ingress of inflammatory leucocytes into the synovium is a crucial step in the
pathogenesis of rheumatoid arthritis (RA). Cytokines are mediators involved in the …

Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis

S Mateen, A Zafar, S Moin, AQ Khan, S Zubair - Clinica chimica acta, 2016 - Elsevier
Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown
etiology. It is characterized by the presence of rheumatoid factor and anti-citrullinated …

Cytokine networks in the pathogenesis of rheumatoid arthritis

N Kondo, T Kuroda, D Kobayashi - International journal of molecular …, 2021 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …