Background The production of lipid-laden cells in macrophages after significant ingestion of
oxidized low-density lipoprotein is considered the most critical phase in the creation of …

Foam cell formation and further accumulation in the subendothelial space of the vascular
wall is a hallmark of atherosclerotic lesions. Targeting foam cell formation in the …

Lipid-laden peripheral tissue cells release cholesterol to an extracellular acceptor such as
high-density lipoprotein (HDL). Foam cells are formed at the first stage of atherosclerosis …

Arterial macrophage foam cells are filled with cholesterol ester (CE) stored in cytosolic lipid
droplets (LDs). Foam cells are central players in progression of atherosclerosis as regulators …

Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is
maintained by specialized cells, such as macrophages. Macrophages express a variety of …

Atherosclerosis can be regarded as a chronic disease derived from the interaction between
disordered lipoproteins and an unsuitable immune response. The evolution of foam cells is …

Foam cells derived from macrophages have been implicated as markers of early stage
atherosclerosis development. In this study, we found that N-acetyl cysteine (NAC), a well …

The formation of foam cells, lipid-loaded macrophages, is the hallmark event of
atherosclerosis. Since cigarette smoking is a risk factor for developing atherosclerosis, the …

Atherosclerosis is associated with acute cardiovascular conditions, such as ischemic heart
disease, myocardial infarction, and stroke, and is the leading cause of morbidity and …

Foam cells are the main pathological components of atherosclerosis. Therapies reducing
foam cell formation can effectively prevent atherosclerotic diseases and cardiovascular …