Quantitative organic acids in urine by two dimensional gas chromatography-time of flight mass spectrometry (GCxGC-TOFMS)

L Sweetman, P Ashcraft, J Bennett-Firmin - Clinical Applications of Mass …, 2016 - Springer
Seventy-six organic acids in urine specimens are determined with quantitative two
dimensional Gas Chromatography-Time of Flight Mass Spectrometry (GCxGC-TOFMS). The …

Metabolic profiling of infant urine using comprehensive two-dimensional gas chromatography: application to the diagnosis of organic acidurias and biomarker …

KA Kouremenos, J Pitt, PJ Marriott - Journal of Chromatography A, 2010 - Elsevier
Comprehensive two-dimensional gas chromatography (GC× GC) time-of-flight mass
spectrometry (ToFMS) was applied to the analysis of urinary organic acids from patients with …

Improvement of sample throughput using fast gas chromatography mass-spectrometry for biochemical diagnosis of organic acid disorders

S Kawana, K Nakagawa, Y Hasegawa, H Kobayashi… - Clinica Chimica …, 2008 - Elsevier
BACKGROUND: Gas chromatograph mass-spectrometric (GC/MS) method of analysis for
urinary organic acids is used for the diagnosis of a variety of metabolic disorders. The …

Urine organic acid analysis for inherited metabolic disease using gas chromatography-mass spectrometry

PM Jones, MJ Bennett - … Applications of Mass Spectrometry: Methods and …, 2010 - Springer
Urine organic acid analysis is an essential component of the workup of the patient
suspected to have an inborn error of metabolism (IEM). Urine contains several hundred …

Automated metabolic profiling and interpretation of GC/MS data for organic acidemia screening: a personal computer-based system

M Kimura, T Yamamoto, S Yamaguchi - The Tohoku journal of …, 1999 - jstage.jst.go.jp
抄録 We have developed a personal computer-based system designed for automated
metabolic profiling of urinary organic acids by gas chromatography-mass spectrometry …

A GC/MS/MS screening method for multiple organic acidemias from urine specimens

T Hagen, MS Korson, M Sakamoto, JE Evans - Clinica chimica acta, 1999 - Elsevier
A gas chromatography tandem mass spectrometry method using an ion trap GC/MS system
was developed to quickly screen urine samples for 14 organic acids associated with multiple …

High resolution gas chromatographic/real-time high resolution mass spectrometric identification of organic acids in human urine

S Lewis, CN Kenyon, J Meili… - Analytical …, 1979 - ACS Publications
A specialized gas chromatography/mass spectrometry/computer (GC/MS/COM) system is
described which combines the efficiency of high resolution gas chromatography (HRGC) …

Automated profiling of urinary organic acids by dual‐column gas chromatography and gas chromatography/mass spectrometry

MF Lefevere, BJ Verhaeghe… - Biomedical & …, 1988 - Wiley Online Library
A multi‐stage screening and identification scheme for the diagnosis of inborn errors in
amino acid, fatty acid, carbohydrate and intermediary metabolism is described. The method …

Analysis of urinary organic acids by gas chromatography tandem mass spectrometry method for metabolic profiling applications

T Mouskeftara, C Virgiliou, G Theodoridis… - … of Chromatography A, 2021 - Elsevier
A sensitive, accurate and precise method was developed for the quantification of a large
number of organic acids in human urine by GC-MS/MS. The analytes were selected based …

Screening of Organic Acidurias by Gas Chromatography–Mass Spectrometry (GC–MS)

D Scott, C Clinton Frazee III, U Garg - Clinical Applications of Mass …, 2022 - Springer
Organic acidurias or acidemias are a group of diverse disorders caused by decreased or
diminished activity of specific enzyme or transporter involved in the metabolism of amino …