PTEN: life as a tumor suppressor
L Simpson, R Parsons - Experimental cell research, 2001 - Elsevier
PTEN, a tumor suppressor located at chromosome 10q23, is mutated in a variety of sporadic
cancers and in two autosomal dominant hamartoma syndromes. PTEN is a phosphatase …
cancers and in two autosomal dominant hamartoma syndromes. PTEN is a phosphatase …
PTEN level in tumor suppression: how much is too little?
The importance of PTEN (phosphatase and tensin homolog located on chromosome 10) in
cancer has surpassed all predictions and expectations from the time it was discovered and …
cancer has surpassed all predictions and expectations from the time it was discovered and …
PTEN C-terminal deletion causes genomic instability and tumor development
Tumor suppressor PTEN controls genomic stability and inhibits tumorigenesis. The N-
terminal phosphatase domain of PTEN antagonizes the PI3K/AKT pathway, but its C …
terminal phosphatase domain of PTEN antagonizes the PI3K/AKT pathway, but its C …
The functions and regulation of the PTEN tumour suppressor
MS Song, L Salmena, PP Pandolfi - Nature reviews Molecular cell …, 2012 - nature.com
The importance of the physiological function of phosphatase and tensin homologue (PTEN)
is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3 …
is illustrated by its frequent disruption in cancer. By suppressing the phosphoinositide 3 …
PTEN and the PI3-kinase pathway in cancer
N Chalhoub, SJ Baker - Annual Review of Pathology …, 2009 - annualreviews.org
PI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-
kinase pathway, which regulates growth, survival, and proliferation. These key signaling …
kinase pathway, which regulates growth, survival, and proliferation. These key signaling …
PTEN expression in non–small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration
The tumor suppressor PTEN encodes a lipid phosphatase that negatively regulates the
phosphatidylinositol 3-kinase/AKT cell survival pathway. Mutations of this gene are common …
phosphatidylinositol 3-kinase/AKT cell survival pathway. Mutations of this gene are common …
New insights into PTEN
T Tamguney, D Stokoe - Journal of cell science, 2007 - journals.biologists.com
The functions ascribed to PTEN have become more diverse since its discovery as a putative
phosphatase mutated in many human tumors. Although it can dephosphorylate lipids and …
phosphatase mutated in many human tumors. Although it can dephosphorylate lipids and …
PTEN: The down side of PI 3-kinase signalling
NR Leslie, CP Downes - Cellular signalling, 2002 - Elsevier
The PTEN tumour suppressor protein is a phosphoinositide 3-phosphatase that, by
metabolising phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P3), acts in direct …
metabolising phosphatidylinositol 3, 4, 5-trisphosphate (PtdIns (3, 4, 5) P3), acts in direct …
The complexity of PTEN: mutation, marker and potential target for therapeutic intervention
LS Steelman, FE Bertrand… - Expert opinion on …, 2004 - Taylor & Francis
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a phosphatase
that removes phosphates primarily from lipids. It has also been called mutated in multiple …
that removes phosphates primarily from lipids. It has also been called mutated in multiple …