Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a non-redundant
lipid phosphatase that restrains and fine tunes the phosphatidylinositol-3-kinase (PI3K) …

The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphatase
dephosphorylates PIP3, the lipid product of the class I PI 3-kinases, and suppresses the …

Alterations in the tumor suppressor phosphatase and tensin homolog (PTEN) occur in a
substantial proportion of solid tumors. These events drive tumorigenesis and tumor …

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is one of the most
frequently disrupted tumor suppressors in cancer. The lipid phosphatase activity of PTEN …

PTEN/PI3K/AKT constitutes an important pathway regulating the signaling of multiple
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …

The tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN)
has a well-characterized lipid phosphatase activity and a poorly characterized protein …

The PTEN gene is one of the most frequently inactivated tumor suppressor genes in
sporadic cancers. Inactivating mutations and deletions of the PTEN gene are found in many …

Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …

The PI3K-Akt pathway is a major survival pathway activated in cancer. Efforts to develop
targeted therapies have not been fully successful, mainly because of extensive internal …

The tumor suppressor gene PTEN is a phosphoinositide phosphatase that is inactivated by
deletion and/or mutation in diverse human tumors. Wild-type PTEN is expressed both in the …