Defibrotide, a polydeoxyribonucleotide extracted from mammalian organs (laboratory code
Fraction P), displays antithrombotic activity after oral administration on different animal …

Defibrotide is a partially depolymerized DNA fraction, having a molecular weight of about
20,000 and possessing antithrombotic and fibrinolytic activities. The present study was …

Defibrotide is a polydeoxyribonucleotide sodium salt with antithrombotic properties. These
properties have been attributed to its profibrinolytic activity [increase of tissue plasminogen …

Defibrotide (D) is a natural polydeoxyribonucleotide from mammalian lungs with
profibrinolytic and antithrombotic activities. D also has PGI 2-stimulating and tissue …

Varying times after administration of defibrotide/placebo to the rabbit, the entire thoracic
aorta was carefully isolated and dissected, starting as close to the heart as possible. It was …

Defibrotide is a polydeoxyribonucleotide extracted from mammalian organs (porcine) and
prepared by controlled depolymerization, resulting in a single-stranded deoxyribonucleotide …

The antithrombotic activity of Fraction P (FP), a polydeoxyribonucleotide extracted from
mammalian organs, was studied in different models of experimental thrombosis. FP displays …

We investigated the effects of Defibrotide (D), a natural polydeoxyribonucleotide, on acute
myocardial ischemia (AMI) in anesthetized cats. A permanent ligature was placed around …

Defibrotide, a polydeoxyribonucleotide, has been found to modulate endothelial cell
function, causing an increase in tissue plasminogen activator (t-PA) levels, a decrease in …

Defibrotide is a single-stranded DNA fraction obtained from mammalian lung and is able to
increase prostacyclin production by endothelial cells. It has profibrinolytic and antithrombotic …