Hyperhomocysteinemia is associated with increased risk for cardiovascular events, but it is
not certain whether it is a mediator of vascular dysfunction or a marker for another risk factor …

Hyperhomocysteinemia is a risk factor for stroke, myocardial infarction, and venous
thrombosis. Moderate hyperhomocysteinemia is associated with impaired endothelial …

▪ Abstract Homocysteine is a sulfur amino acid whose metabolism stands at the intersection
of two pathways: remethylation to methionine, which requires folate and vitamin B12 (or …

The homocysteine theory of arteriosclerosis received credence when it was shown that after
a methionine load, circulating homocysteine–cysteine concentrations were higher in …

Based on recent retrospective, prospective, and experimental studies, mild to moderate
elevation of fasting or postmethionine-load plasma homocysteine is accepted as an …

Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease,
including ischemic heart disease, stroke, and peripheral vascular disease. Mutations in the …

Methionine is the precursor of homocysteine, a sulfur amino acid intermediate in the
methylation and transsulfuration pathways. Elevated plasma homocysteine …

Genetic disorders of homocysteine (Hcy) metabolism or a high‐methionine diet lead to
elevations of plasma Hcy levels. In humans, severe genetic hyperhomocysteinemia results …

Homocysteine is a sulfur-containing aminoacid produced during metabolism of methionine.
Since 1969 the relationship between altered homocysteine metabolism and both coronary …

Hyperhomocysteinemia is an established risk factor for arterial as well as venous
thromboembolism. Individuals with severe hyperhomocysteinemia caused by inherited …