Pyruvate kinase M2 sustains cardiac mitochondrial quality surveillance in septic cardiomyopathy by regulating prohibitin 2 abundance via S91 phosphorylation
Y Du, J Li, Z Dai, Y Chen, Y Zhao, X Liu, T Xia… - Cellular and Molecular …, 2024 - Springer
The endogenous mitochondrial quality control (MQC) system serves to protect mitochondria
against cellular stressors. Although mitochondrial dysfunction contributes to cardiac damage …
against cellular stressors. Although mitochondrial dysfunction contributes to cardiac damage …
[HTML][HTML] Pyruvate kinase M2 sustains cardiac mitochondrial integrity in septic cardiomyopathy by regulating PHB2-dependent mitochondrial biogenesis
J Ren, B Ren, T Fu, Y Ma, Y Tan, S Zhang… - … Journal of Medical …, 2024 - ncbi.nlm.nih.gov
Previous studies have highlighted the protective effects of pyruvate kinase M2 (PKM2)
overexpression in septic cardiomyopathy. In our study, we utilized cardiomyocyte-specific …
overexpression in septic cardiomyopathy. In our study, we utilized cardiomyocyte-specific …
PKM2 interacts with and phosphorylates PHB2 to sustain mitochondrial quality control against septic cerebral-cardiac injury
Y Zhao, Y Pan, M Chen, Y Tan, X Chang, H Li… - International Journal of …, 2024 - medsci.org
Sepsis induces profound disruptions in cellular homeostasis, particularly impacting
mitochondrial function in cardiovascular and cerebrovascular systems. This study elucidates …
mitochondrial function in cardiovascular and cerebrovascular systems. This study elucidates …
[HTML][HTML] Receptor-Interacting Protein Kinase 3 Suppresses Mitophagy Activation via the Yes-Associated Protein/Transcription Factor EB Pathways in Septic …
P Zhu, Y Chen, J Wang, G Lin, R Wang… - Frontiers in …, 2022 - frontiersin.org
Mitophagy, known as the main mechanism of mitochondrial quality control, determines the
pathophysiology of septic cardiomyopathy, although the precise regulatory mechanisms …
pathophysiology of septic cardiomyopathy, although the precise regulatory mechanisms …
M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics
L Guo, L Wang, G Qin, J Zhang, J Peng, L Li… - Journal of Translational …, 2023 - Springer
Background Right ventricle failure (RVF) is a progressive heart disease that has yet to be
fully understood at the molecular level. Elevated M-type pyruvate kinase 2 (PKM2) …
fully understood at the molecular level. Elevated M-type pyruvate kinase 2 (PKM2) …
[HTML][HTML] Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome
N Liu, Y Ding, H Zhou, X Chang… - International Journal of …, 2024 - ncbi.nlm.nih.gov
Abstract Type-3 cardiorenal syndrome (CRS-3) is acute kidney injury followed by cardiac
injury/dysfunction. Mitochondrial injury may impair myocardial function during CRS-3. Since …
injury/dysfunction. Mitochondrial injury may impair myocardial function during CRS-3. Since …
[HTML][HTML] Pgam5-mediated PHB2 dephosphorylation contributes to endotoxemia-induced myocardial dysfunction by inhibiting mitophagy and the mitochondrial …
C Cai, Z Li, Z Zheng, Z Guo, Q Li, S Deng… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Numerous mitochondrial abnormalities are reported to result from excessive inflammation
during endotoxemia. Prohibitin 2 (PHB2) and phosphoglycerate mutase 5 (Pgam5) have …
during endotoxemia. Prohibitin 2 (PHB2) and phosphoglycerate mutase 5 (Pgam5) have …
TMBIM6 prevents VDAC1 multimerization and improves mitochondrial quality control to reduce sepsis-related myocardial injury
Background The regulatory mechanisms involved in mitochondrial quality control (MQC)
dysfunction during septic cardiomyopathy (SCM) remain incompletely characterized …
dysfunction during septic cardiomyopathy (SCM) remain incompletely characterized …
PKM2 deficiency exacerbates gram-negative sepsis-induced cardiomyopathy via disrupting cardiac calcium homeostasis
L Ni, B Lin, M Shen, C Li, L Hu, F Fu, L Chen… - Cell Death …, 2022 - nature.com
Sepsis is a life-threatening syndrome with multi-organ dysfunction in critical care medicine.
With the occurrence of sepsis-induced cardiomyopathy (SIC), characterized by reduced …
With the occurrence of sepsis-induced cardiomyopathy (SIC), characterized by reduced …
MKP1 overexpression reduces TNF‐α‐induced cardiac injury via suppressing mitochondrial fragmentation and inhibiting the JNK–MIEF1 pathways
W Chang, M Feng, Y Li, Y Sun… - Journal of Cellular …, 2019 - Wiley Online Library
Mitochondrial stress has been acknowledged as the pathogenesis for tumor necrosis factor‐
α (TNF‐α)‐induced septic cardiomyopathy. Recently, MAP kinase phosphatase 1 (MKP1) …
α (TNF‐α)‐induced septic cardiomyopathy. Recently, MAP kinase phosphatase 1 (MKP1) …