Objectives Dual specificity phosphatase 1 (DUSP1) is regarded as an anti-inflammatory
factor in cardiovascular disorders. Mitophagy removes damaged mitochondria and thus …

Background In sepsis, circulating cytokines and lipopolysaccharide elicit mitochondrial
dysfunction and cardiomyopathy, a major cause of morbidity and mortality with this …

Hypobaric hypoxia (HH) is the primary challenge at highland. Prolonged HH exposure
impairs right cardiac function. Mitochondria-associated membrane (MAM) plays a principal …

Mitochondrial fission and selective mitochondrial autophagy (mitophagy) form an essential
axis of mitochondrial quality control that plays a critical role in the development of cardiac …

Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

Septic cardiomyopathy (SCM) is associated with an imbalance in mitochondrial quality and
high mortality rates, with no effective treatment developed to date. Curcumin provides …

PKCε is central to cardioprotection. Sub‐proteome analysis demonstrated co‐localization of
activated cardiac PKCε (aPKCε) with metabolic, mitochondrial, and cardioprotective …

Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy
and the mitochondrial unfolded protein response (UPR mt) are the predominant stress …

Maintenance of normal function of mitochondria is vital to the fate and health of
cardiomyocytes. Mitochondrial quality control (MQC) mechanisms are essential in governing …

Limited understanding of the mechanisms responsible for life-threatening organ and
immune failure hampers scientists' ability to design sepsis treatments. Pyruvate …