Introduction MrpC, a member of the CRP/Fnr transcription factor superfamily, is necessary to
induce and control the multicellular developmental program of the bacterium, Myxococcus …

Background Myxococcus xanthus is a bacterium that undergoes multicellular development
when starved. Cells move to aggregation centers and form fruiting bodies in which cells …

Transcription factor autoregulation is a simple network motif (recurring circuit) built into
genetic regulatory networks that direct cell behavior. Negative autoregulation (NAR) network …

Myxococcus xanthus is an excellent model system for multicellular prokaryotic behaviour
and Gram-negative differentiation. Under nutrient-limited conditions, the population enters a …

MrpC, a member of the CRP/Fnr superfamily of transcriptional regulators, plays a key role in
coordination of the multicellular developmental program in Myxococcus xanthus. Previous …

The developmental process of Myxococcus xanthus is achieved by the expression of a
specific set of genes under the influence of developmental signals. MrpC is a member of the …

Upon depletion of nutrients, Myxococcus xanthus forms mounds on a solid surface. The
differentiation of rod-shaped cells into stress-resistant spores within mounds creates mature …

Summary The Crp/Fnr family of transcriptional regulators play central roles in transcriptional
control of diverse physiological responses, and are activated by a surprising diversity of …

Starvation causes cells in a dense population of Myxococcus xanthus to change their gliding
movements and construct mounds. Short-range C-signaling between rod-shaped cells …

Starved Myxococcus xanthus cells glide to aggregation centers and form fruiting bodies in
which rod-shaped cells differentiate into ovoid spores. Commitment to development was …