This study aims to develop amorphous solid dispersion (ASD) of lumefantrine with a cost-
effective approach of spray anti-solvent precipitation. Four acidic polymers …

Amorphous solid dispersions (ASDs) of lumefantrine, which has low aqueous solubility,
have been shown to improve bioavailability relative to crystalline formulations. Herein, the …

Amorphous solid dispersions (ASDs) are of great interest due to their ability to enhance the
delivery of poorly soluble drugs. Recent studies have shown that, in addition to acting as a …

Glass transition temperature (T g) is important for amorphous compounds because it can
have implications on their physical and chemical stability. With drugs that possess ionizable …

This study investigates drug-excipient interactions in amorphous solid dispersions (ASDs) of
the model basic compound lumefantrine (LMN), with five acidic polymers. X-ray …

Abstract Lumefantrine (LMF), a high-mobility and easy-to-crystallize WHO drug for treating
malaria, can form an amorphous salt with poly (acrylic acid)(PAA) that is remarkably stable …

The interest in hot-melt extrusion as a drug delivery technology for the production of solid
dispersion is growing rapidly. Lumefantrine (LUMF) is an antimalarial drug that exhibits poor …

The aim of this study was to investigate the industrial feasibility of developing a co-
formulated solid dispersion (SD) containing two antimalarial drugs artemether (ARTM) and …

The objective of this study was to explore the feasibility of using alginate as a promising
diphase solid dispersion carrier to enhance dissolution rate of BCS II drugs with improved …

The present study was designed to determine the applicability of a newly derived
dimensionless number precipitation parameter,“supersaturation holding capacity (SHC)” in …