Abstract Neurexin 1 (NRXN1), a presynaptic cell adhesion molecule, is implicated in several
neurodevelopmental disorders characterized by synaptic dysfunction including autism …

Abstract Neurexin 1 (NRXN1) is a large presynaptic transmembrane protein that has
complex and variable patterns of expression in the brain. Sequence variants in NRXN1 are …

Many neuropsychiatric and neurodevelopmental disorders commonly share genetic risk
factors. To date, the mechanisms driving the pathogenesis of these disorders, particularly …

Background Copy number variants have emerged as an important genomic cause of
common, complex neurodevelopmental disorders. These usually change copy number of …

Neurexins are a family of presynaptic cell adhesion proteins that regulate synaptic structure
and maintain normal synaptic transmission. Mutations in the α-isoform of neurexin1-gene …

Synapses, highly specialized membrane junctions between neurons, connect presynaptic
neurotransmitter release sites and postsynaptic ligand‐gated channels. Neurexins (Nrxns) …

Autism is a common and frequently disabling neurodevelopmental disorder with a strong
genetic basis. Human genetic studies have discovered mutations disrupting exons of the …

Neurexins are a family of presynaptic single-pass transmembrane proteins that act as
synaptic organizers in mammals. The neurexins consist of three genes (NRXN1, NRXN2 …

Human genetics has identified rare copy number variations and deleterious mutations for all
neurexin genes (NRXN1-3) in patients with neurodevelopmental diseases, and …

Neurexins are presynaptic transmembrane proteins crucial for synapse development and
organization. Deletion and missense mutations in all three Neurexin genes have been …