Background Bacterial communities in humans, animals, and the external environment
maintain a large collection of antibiotic resistance genes (ARGs). However, few of these …

Antibiotic resistance is a dire clinical problem with important ecological dimensions. While
antibiotic resistance in human pathogens continues to rise at alarming rates, the impact of …

Background The impact of human activities on the environmental resistome has been
documented in many studies, but there remains the controversial question of whether the …

Abstract Background Antibiotic resistance genes (ARGs) are widespread but cause
problems only when present in pathogens. Environments where selection and transmission …

The global crisis in antimicrobial resistance continues to grow. Estimating the risks of
antibiotic resistance transmission across habitats is hindered by the lack of data on mobility …

The antibiotic resistance is natural in bacteria and predates the human use of antibiotics.
Numerous antibiotic resistance genes (ARGs) have been discovered to confer resistance to …

The concept of the antibiotic resistome was introduced just over a decade ago, and since
then, active resistome studies have been conducted. In the present study, we describe the …

Application of metagenomic functional selections to study antibiotic resistance genes is
revealing a highly diverse and complex network of genetic exchange between bacterial …

Antibiotic resistance is an ancient problem, owing to the co-evolution of antibiotic-producing
and target organisms in the soil and other environments over millennia. The environmental …

In a recent Opinion article (What is a resistance gene? Ranking risks in resistomes. Nature
Rev. Microbiol. 13, 116–123 (2015)) 1, Martínez et al. outline the obstacles associated with …