[HTML][HTML] Relevance of caspase-1 and Nlrp3 inflammasome on inflammatory bone resorption in a murine model of periodontitis
FRG Rocha, AE Delitto, JAC de Souza… - Scientific reports, 2020 - nature.com
This study investigates the role of NLRP3 inflammasome and its main effector Caspase-1 in
inflammation and alveolar bone resorption associated with periodontitis. Heat-killed …
inflammation and alveolar bone resorption associated with periodontitis. Heat-killed …
NLRP3 regulates alveolar bone loss in ligature‐induced periodontitis by promoting osteoclastic differentiation
Y Chen, Q Yang, C Lv, Y Chen, W Zhao, W Li… - Cell …, 2021 - Wiley Online Library
Objectives NLRP3 inflammasome is a critical part of the innate immune system and plays an
important role in a variety of inflammatory diseases. However, the effects of NLRP3 …
important role in a variety of inflammatory diseases. However, the effects of NLRP3 …
Targeting NLRP3 inflammasome reduces age-related experimental alveolar bone loss
Y Zang, JH Song, SH Oh, JW Kim… - Journal of Dental …, 2020 - journals.sagepub.com
The cause of chronic inflammatory periodontitis, which leads to the destruction of
periodontal ligament and alveolar bone, is multifactorial. An increasing number of studies …
periodontal ligament and alveolar bone, is multifactorial. An increasing number of studies …
[HTML][HTML] The role of cytokines produced via the NLRP3 inflammasome in mouse macrophages stimulated with dental calculus in osteoclastogenesis
M Mae, MI Alam, Y Yamashita, Y Ozaki… - International Journal of …, 2021 - mdpi.com
Dental calculus (DC) is a common deposit in periodontitis patients. We have previously
shown that DC contains both microbial components and calcium phosphate crystals that …
shown that DC contains both microbial components and calcium phosphate crystals that …
[HTML][HTML] NLRP3 inflammasome negatively regulates RANKL-induced osteoclastogenesis of mouse bone marrow macrophages but positively regulates it in the …
In inflammatory bone diseases such as periodontitis, the nucleotide-binding oligomerization
domain, leucine-rich repeat, and pyrin domain-containing 3 (NLRP3) inflammasome …
domain, leucine-rich repeat, and pyrin domain-containing 3 (NLRP3) inflammasome …
[HTML][HTML] Activation of the NLRP3/caspase-1 inflammasome in human dental pulp tissue and human dental pulp fibroblasts
W Jiang, H Lv, H Wang, D Wang, S Sun, Q Jia… - Cell and Tissue …, 2015 - Springer
Abstract The NLRP3/caspase-1 inflammasome pathway plays an important role in cellular
immune defence against bacterial infection; however, its function in human dental pulp …
immune defence against bacterial infection; however, its function in human dental pulp …
Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease
Y Yamaguchi, T Kurita-Ochiai, R Kobayashi… - Inflammation …, 2017 - Springer
Objective Porphyromonas gingivalis is involved in the pathogenesis of chronic inflammatory
periodontal disease. Recent studies have suggested that the NLRP3 inflammasome plays …
periodontal disease. Recent studies have suggested that the NLRP3 inflammasome plays …
[HTML][HTML] The role of NLRP3 inflammasome activities in bone diseases and vascular calcification
C Yu, C Zhang, Z Kuang, Q Zheng - Inflammation, 2021 - Springer
Continuous stimulation of inflammation is harmful to tissues of an organism. Inflammatory
mediators not only have an effect on metabolic and inflammatory bone diseases but also …
mediators not only have an effect on metabolic and inflammatory bone diseases but also …
[HTML][HTML] NLRP3 is involved in neutrophil mobilization in experimental periodontitis
B Cheat, C Torrens, A Foda, B Baroukh… - Frontiers in …, 2022 - frontiersin.org
The NLRP3 inflammasome is overexpressed in gingiva of periodontitis patients but its role
remains unclear. In our study, we use a periodontitis mouse model of ligature, impregnated …
remains unclear. In our study, we use a periodontitis mouse model of ligature, impregnated …
[HTML][HTML] The role of inflammasome NLPR3 in the development and therapy of periodontitis
Y Zhao, Y Quan, T Lei, L Fan, X Ge… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Periodontitis is a chronic inflammatory disease that affects tooth-supporting tissues and even
leads to tooth loss. NLRP3 inflammasomes play a critical role in periodontitis pathogenesis …
leads to tooth loss. NLRP3 inflammasomes play a critical role in periodontitis pathogenesis …