This study investigates the role of NLRP3 inflammasome and its main effector Caspase-1 in
inflammation and alveolar bone resorption associated with periodontitis. Heat-killed …

Objectives NLRP3 inflammasome is a critical part of the innate immune system and plays an
important role in a variety of inflammatory diseases. However, the effects of NLRP3 …

The cause of chronic inflammatory periodontitis, which leads to the destruction of
periodontal ligament and alveolar bone, is multifactorial. An increasing number of studies …

Dental calculus (DC) is a common deposit in periodontitis patients. We have previously
shown that DC contains both microbial components and calcium phosphate crystals that …

In inflammatory bone diseases such as periodontitis, the nucleotide-binding oligomerization
domain, leucine-rich repeat, and pyrin domain-containing 3 (NLRP3) inflammasome …

Abstract The NLRP3/caspase-1 inflammasome pathway plays an important role in cellular
immune defence against bacterial infection; however, its function in human dental pulp …

Objective Porphyromonas gingivalis is involved in the pathogenesis of chronic inflammatory
periodontal disease. Recent studies have suggested that the NLRP3 inflammasome plays …

Continuous stimulation of inflammation is harmful to tissues of an organism. Inflammatory
mediators not only have an effect on metabolic and inflammatory bone diseases but also …

The NLRP3 inflammasome is overexpressed in gingiva of periodontitis patients but its role
remains unclear. In our study, we use a periodontitis mouse model of ligature, impregnated …

Periodontitis is a chronic inflammatory disease that affects tooth-supporting tissues and even
leads to tooth loss. NLRP3 inflammasomes play a critical role in periodontitis pathogenesis …