Antiphospholipid antibody-mediated disruption of the annexin-V antithrombotic shield: a thrombogenic mechanism for the antiphospholipid syndrome

JH Rand - Journal of autoimmunity, 2000 - Elsevier
The mechanism (s) for thrombosis and pregnancy losses in the anti-phospholipid antibody
syndrome have not yet been established. Annexin-V is an anionic phospholipid-binding …

Annexin A5 in cardiovascular disease and systemic lupus erythematosus

A Cederholm, J Frostegård - Immunobiology, 2005 - Elsevier
Atherosclerosis, a major cause of disease and death from cardiovascular disease (CVD), is
an inflammatory disease characterized by T cell and monocyte/macrophage infiltration in the …

Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo

Z Romay-Penabad… - Blood, The Journal …, 2009 - ashpublications.org
Antiphospholipid (aPL) antibodies recognize receptor-bound β2 glycoprotein I (β2GPI) on
target cells, and induce an intracellular signaling and a procoagulant/proinflammatory …

Correlation between antiphospholipid antibodies that recognize domain I of β2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5

B de Laat, XX Wu, M van Lummel, RHWM Derksen… - Blood, 2007 - ashpublications.org
The paradoxical correlation between thrombosis and the lupus anticoagulant (LAC) effect is
an enigmatic feature of the antiphospholipid (aPL) syndrome. The Dutch authors previously …

The role of TLR 4 in pathophysiology of antiphospholipid syndrome‐associated thrombosis and pregnancy morbidity

H Xie, L Sheng, H Zhou, J Yan - British journal of haematology, 2014 - Wiley Online Library
The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the
clinical features of recurrent thrombosis in the venous or arterial circulation and fetal losses …

Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis

W Ao, H Zheng, XW Chen, Y Shen, CD Yang - Rheumatology …, 2011 - Springer
This study investigated the prevalence of antibody against annexin II (A2) in patients with
antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). It also explored …

Annexin A2 autoantibodies in thrombosis and autoimmune diseases

F Cañas, L Simonin, F Couturaud, Y Renaudineau - Thrombosis research, 2015 - Elsevier
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial,
venous or small-vessel thrombotic events, and recurrent miscarriages or fetal loss. APS …

The antiphospholipid syndrome: still an enigma

S Chaturvedi, KR McCrae - Hematology 2014, the American …, 2015 - ashpublications.org
Antiphospholipid syndrome (APS) is defined by clinical manifestations that include
thrombosis and/or fetal loss or pregnancy morbidity in patients with antiphospholipid …

Antiphospholipid antibodies accelerate plasma coagulation by inhibiting annexin-V binding to phospholipids: a “lupus procoagulant” phenomenon

JH Rand, XX Wu, HAM Andree… - Blood, The Journal …, 1998 - ashpublications.org
The antiphospholipid syndrome is a thrombophilic condition marked by antibodies that
recognize anionic phospholipid-protein cofactor complexes. We recently reported that …

Annexin A2: biology and relevance to the antiphospholipid syndrome

E Cockrell, RG Espinola, KR McCrae - Lupus, 2008 - journals.sagepub.com
Antiphospholipid antibodies (aPL), the majority of which are directed against β2-
glycoprotein I (β2GPI), are associated with an increased incidence of venous and arterial …