The journey of antiphospholipid antibodies from cellular activation to antiphospholipid syndrome

R Willis, EB Gonzalez, AR Brasier - Current Rheumatology Reports, 2015 - Springer
Pathogenic antiphospholipid antibodies (aPL) are the driving factors of recurrent pregnancy
loss and thrombosis that characterize antiphospholipid syndrome (APS). Current evidence …

[HTML][HTML] Complement in the pathophysiology of the antiphospholipid syndrome

S Chaturvedi, RA Brodsky, KR McCrae - Frontiers in immunology, 2019 - frontiersin.org
The antiphospholipid syndrome (APS) is characterized by thrombosis and pregnancy
morbidity in the presence of antiphospholipid antibodies (aPL). Complement is a system of …

Antiphospholipid syndrome in pregnancy: new and old pathogenetic mechanisms

S D'Ippolito, G Barbaro, C Paciullo, C Tersigni… - International journal of …, 2023 - mdpi.com
The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized,
according to the Sydney criteria, by the persistent presence of autoantibodies directed …

Antiphospholipid antibody syndrome: new insights on thrombogenic mechanisms

JH Rand - The American journal of the medical sciences, 1998 - Elsevier
The anti phospholipid antibody syndrome is a thrombophilic condition manifested by
vascular thrombosis or recurrent pregnancy loss together with the presence of antibodies …

Antiphospholipid syndrome: pathogenesis and a window of treatment opportunities in the future

AA Mehdi, I Uthman… - European journal of clinical …, 2010 - Wiley Online Library
Eur J Clin Invest 2010; 40 (5): 451–464 Abstract Background Antiphospholipid syndrome
(APS) is a systemic autoimmune vascular disease characterized by recurrent thrombotic …

Pathophysiology of the antiphospholipid antibody syndrome

R Willis, SS Pierangeli - Autoimmunity highlights, 2011 - Springer
Antiphospholipid antibodies (aPL) are associated with the recurrent pregnancy loss and
thrombosis that characterizes the antiphospholipid antibody syndrome (APS). Although the …

Examining the prevalence of non-criteria anti-phospholipid antibodies in patients with anti-phospholipid syndrome: a systematic review

V Rodriguez-Garcia, Y Ioannou… - …, 2015 - academic.oup.com
Objective. To systematically review and establish the prevalence of antibody positivity in
assays not currently included in the APS classification criteria to detect antibodies directed …

[HTML][HTML] Annexin-A5 promotes membrane resealing in human trophoblasts

R Carmeille, SA Degrelle, L Plawinski, F Bouvet… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract Annexin-A5 (AnxA5) is the smallest member of the annexins, a group of soluble
proteins that bind to membranes containing negatively-charged phospholipids, principally …

Competition of annexin V and anticardiolipin antibodies for binding to phosphatidylserine containing membranes

GM Willems, MP Janssen, P Comfurius, M Galli… - Biochemistry, 2000 - ACS Publications
Annexin V, an intracellular protein with a calcium-dependent high affinity for anionic
phospholipid membranes, acts as an inhibitor of lipid-dependent reactions of the blood …

Antiphospholipid immunoglobulin G antibodies reduce annexin-V levels on syncytiotrophoblast apical membranes and in culture media of placental villi

JH Rand, XX Wu, S Guller, J Scher, HAM Andree… - American journal of …, 1997 - Elsevier
OBJECTIVES: The mechanism by which antiphospholipid antibodies are associated with
pregnancy loss and thromboembolism has not been established. We previously showed that …