Interleukin-1 beta—a friend or foe in malignancies?
R Bent, L Moll, S Grabbe, M Bros - International journal of molecular …, 2018 - mdpi.com
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …
Interleukin-1β and cancer
C Rébé, F Ghiringhelli - Cancers, 2020 - mdpi.com
Within a tumor, IL-1β is produced and secreted by various cell types, such as immune cells,
fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a …
fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a …
Roles of IL-1 in cancer: from tumor progression to resistance to targeted therapies
V Gelfo, D Romaniello, M Mazzeschi, M Sgarzi… - International journal of …, 2020 - mdpi.com
IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-
inflammatory activity. Beyond its biological role as a regulator of the innate immune …
inflammatory activity. Beyond its biological role as a regulator of the innate immune …
Unique versus redundant functions of IL-1α and IL-1β in the tumor microenvironment
E Voronov, S Dotan, Y Krelin, X Song… - Frontiers in …, 2013 - frontiersin.org
Interleukin-1 (IL-1) is a major “alarm” upstream pro-inflammatory cytokine that also affects
immunity and hematopoiesis by inducing cytokine cascades. In the tumor arena, IL-1 is …
immunity and hematopoiesis by inducing cytokine cascades. In the tumor arena, IL-1 is …
Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment
AM Lewis, S Varghese, H Xu, HR Alexander - Journal of translational …, 2006 - Springer
The tumor microenvironment consists of tumor, immune, stromal, and inflammatory cells
which produce cytokines, growth factors, and adhesion molecules that promote tumor …
which produce cytokines, growth factors, and adhesion molecules that promote tumor …
The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions
RN Apte, S Dotan, M Elkabets, MR White… - Cancer and Metastasis …, 2006 - Springer
Abstract Interleukin-1 (IL-1) includes a family of closely related genes; the two major
agonistic proteins, IL-1α and IL-1β, are pleiotropic and affect mainly inflammation, immunity …
agonistic proteins, IL-1α and IL-1β, are pleiotropic and affect mainly inflammation, immunity …
The role of IL-1β in the early tumor cell–induced angiogenic response
Y Carmi, S Dotan, P Rider, I Kaplanov… - The Journal of …, 2013 - journals.aai.org
In this study, we assessed the involvement of IL-1β in early angiogenic responses induced
by malignant cells using Matrigel plugs supplemented with B16 melanoma cells. We found …
by malignant cells using Matrigel plugs supplemented with B16 melanoma cells. We found …
Interleukin-1 in tumor progression, therapy, and prevention
C Garlanda, A Mantovani - Cancer cell, 2021 - cell.com
Summary Interleukin-1 (IL-1) is a key orchestrator of inflammation and plays an important
role in tumor progression. Based on preclinical models and human genetic associations, we …
role in tumor progression. Based on preclinical models and human genetic associations, we …
IL-1α processing, signaling and its role in cancer progression
Interleukin-1α (IL-1α) is a major alarmin cytokine which triggers and boosts the inflammatory
responses. Since its discovery in the 1940s, the structure and bioactivity of IL-1α has been …
responses. Since its discovery in the 1940s, the structure and bioactivity of IL-1α has been …
IL‐1 and IL‐1 regulatory pathways in cancer progression and therapy
A Mantovani, I Barajon, C Garlanda - Immunological reviews, 2018 - Wiley Online Library
Inflammation is an important component of the tumor microenvironment. IL‐1 is an
inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL‐1 …
inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL‐1 …