Abstract Interleukin-1β (IL-1β) is a pleiotropic cytokine that exerts multiple roles in both
physiological and pathological conditions. It is produced by different cell subsets, and drives …

Interleukin-1 (IL-1) represents a family of two agonistic proteins, IL-1α and IL-1β, that are
pleiotropic and affect hemopoiesis, inflammation, and immunity. In the context of the …

Here, we describe that microenvironmental IL-1β and, to a lesser extent, IL-1α are required
for in vivo angiogenesis and invasiveness of different tumor cells. In IL-1β knockout (KO) …

Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

IL-6 activates various cell types carrying the membrane bound IL-6R (classical IL-6
signaling) as well as IL-6R− gp130+ cells via the soluble IL-6R (IL-6 trans-signaling). IL-6 …

The aggressive nature of metastatic human cancer has been shown to be related to
numerous abnormalities in growth factors and their receptors. These perturbations confer a …

The interleukin‐1 (IL‐1) family consists of two major agonistic proteins, IL‐1α and IL‐1β,
which are pleiotropic and affect mainly inflammation, immunity, and hemopoiesis. The IL‐1 …

In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …

Abstract Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation
that plays a complex, and sometimes contrasting, role in different stages of cancer …

The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ.
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …