[HTML][HTML] Interleukin-1β as emerging therapeutic target in hematological malignancies and potentially in their complications
L Arranz, M del Mar Arriero, A Villatoro - Blood reviews, 2017 - Elsevier
Abstract Interleukin-1β (IL-1β) is a pleiotropic cytokine that exerts multiple roles in both
physiological and pathological conditions. It is produced by different cell subsets, and drives …
physiological and pathological conditions. It is produced by different cell subsets, and drives …
Interleukin-1—a major pleiotropic cytokine in tumor–host interactions
RN Apte, E Voronov - Seminars in cancer biology, 2002 - Elsevier
Interleukin-1 (IL-1) represents a family of two agonistic proteins, IL-1α and IL-1β, that are
pleiotropic and affect hemopoiesis, inflammation, and immunity. In the context of the …
pleiotropic and affect hemopoiesis, inflammation, and immunity. In the context of the …
IL-1 is required for tumor invasiveness and angiogenesis
E Voronov, DS Shouval, Y Krelin… - Proceedings of the …, 2003 - National Acad Sciences
Here, we describe that microenvironmental IL-1β and, to a lesser extent, IL-1α are required
for in vivo angiogenesis and invasiveness of different tumor cells. In IL-1β knockout (KO) …
for in vivo angiogenesis and invasiveness of different tumor cells. In IL-1β knockout (KO) …
IL-6 and related cytokines as the critical lynchpins between inflammation and cancer
K Taniguchi, M Karin - Seminars in immunology, 2014 - Elsevier
Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …
promotion, progression, and metastasis. Cytokines are now recognized as important …
IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
MF Neurath, S Finotto - Cytokine & growth factor reviews, 2011 - Elsevier
IL-6 activates various cell types carrying the membrane bound IL-6R (classical IL-6
signaling) as well as IL-6R− gp130+ cells via the soluble IL-6R (IL-6 trans-signaling). IL-6 …
signaling) as well as IL-6R− gp130+ cells via the soluble IL-6R (IL-6 trans-signaling). IL-6 …
Interleukin-8 and human cancer biology
K Xie - Cytokine & growth factor reviews, 2001 - Elsevier
The aggressive nature of metastatic human cancer has been shown to be related to
numerous abnormalities in growth factors and their receptors. These perturbations confer a …
numerous abnormalities in growth factors and their receptors. These perturbations confer a …
Is interleukin‐1 a good or bad 'guy'in tumor immunobiology and immunotherapy?
RN Apte, E Voronov - Immunological reviews, 2008 - Wiley Online Library
The interleukin‐1 (IL‐1) family consists of two major agonistic proteins, IL‐1α and IL‐1β,
which are pleiotropic and affect mainly inflammation, immunity, and hemopoiesis. The IL‐1 …
which are pleiotropic and affect mainly inflammation, immunity, and hemopoiesis. The IL‐1 …
Role of interleukin-6 in cancer progression and therapeutic resistance
In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …
reduced significantly despite phenomenal advances in the technologies related to diagnosis …
IL-1 signaling in tumor microenvironment
W Zhang, N Borcherding, R Kolb - … : The Role of Interleukins–Part A, 2020 - Springer
Abstract Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation
that plays a complex, and sometimes contrasting, role in different stages of cancer …
that plays a complex, and sometimes contrasting, role in different stages of cancer …
The IL-1 family in tumorigenesis and antitumor immunity
The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ.
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …