We have previously described the expression of interleukin cytokines (IL)-1α, IL-1β, and IL-1
receptor antagonist (IL-1ra) in human breast cancer (HBC) tissue. Based on our previous …

IL-18 is a proinflammatory and immune regulatory cytokine, member of the IL-1 family. IL-18
was initially identified as an IFN-γ-inducing factor in T and NK cells, involved in Th1 …

Interleukin (IL) 6 has been suggested to be the major cytokine responsible for proliferation of
neoplastic plasma cells in both human myeloma and mouse plasmacytoma. Much of the …

Interleukin-6 (IL-6) is a cytokine that plays a prominent role in the coordinated systemic host
defense response to injury. It regulates adaptation of different organ systems and …

Tumor progression relies on the ability of cancer cells to effectively invade surrounding
tissues and propagate. Among the many mechanisms that contribute to tumor progression is …

The idea of a potential link between cancer and inflammation was first proposed by R.
Virchow in the nineteenth century. However, clear evidence regarding a key role of …

ABSTRACT Interleukin-2 (IL-2) is one of the key cytokines with pleiotropic effects on immune
system. It has been approved for the treatment of metastatic renal cell carcinoma and …

In the recently published paper by Xie et al1 in the journal ofDrug Design, Development and
Therapy, the authors have evaluated interleukin (IL)-17–driven inflammatory responses in …

Interleukin 6 (IL-6), which was originally identified as a B-cell differentiation factor, is now
known to be a multifunctional cytokine that regulates the immune response, hematopoiesis …

Abstract Interleukin (IL)-4 is a crucial cytokine in tumor immunology. In the initial murine
experiments, IL-4 exhibited potent anti-tumor ability. Tumors genetically modified to produce …