Vascular endothelial cells synthesize nitric oxide (NO) in response to agonists that elevate
cytosolic free Ca2+ concentrations. Once activated, NO synthase (NOS) requires arginine …

Expression and localization of nitric oxide synthase (NOS) in the lungs of chronically hypoxic
and normoxic rats were studied using both immunohistochemistry and NADPH diaphorase …

We examined whether overproduction of endogenous nitric oxide (NO) can prevent hypoxia-
induced pulmonary hypertension and vascular remodeling by using endothelial NO …

Cigarette smoking has been associated with alterations in the structure and endothelial
function of pulmonary arteries. Nitric oxide (NO) and endothelin-1 are endothelium-derived …

Nitric oxide plays an important role in modulating pulmonary vascular tone. All three
isoforms of nitric oxide synthase (NOS), neuronal (nNOS, NOS I), inducible (iNOS, NOS II) …

Background The importance of nitric oxide (NO) in hypoxic pulmonary hypertension has
been demonstrated using nitric oxide synthase (NOS) knockout mice. In that model NO from …

Inorganic nitrite has recently been recognized to possess vascular activity that is enhanced
in hypoxia. This has been demonstrated in humans in the forearm vascular bed. In animal …

There is indirect, contradictory evidence both for increased and reduced synthesis of the
endothelium-derived vasodilator, nitric oxide, in the pulmonary circulation during acute …

Autophagy is a process for cells to degrade proteins or entire organelles to maintain a
balance in the synthesis, degradation, and subsequent recycling of cellular products …

Primary pulmonary hypertension (PPH) is a rare and fatal disease of unknown etiology.
Inflammatory oxidant mechanisms and deficiency in nitric oxide (NO) have been implicated …