Objectives. This investigation sought to determine whether endothelium-derived nitric oxide
contributes to hypoxia-induced systemic vasodilation and pulmonary vasoconstriction in …

Significance: Pulmonary arterial hypertension (PAH) is a disorder characterized by
increased pulmonary vascular resistance and mean pulmonary artery pressure leading to …

Nitric oxide (NO) signaling plays a major role in modulating vascular tone and remodeling in
the pulmonary circulation, but its role in the pathogenesis of pulmonary vascular diseases is …

Abstract Pulmonary Arterial Hypertension (PAH) is a disease of the pulmonary vasculature
leading to vasoconstriction and remodeling of the pulmonary arteries. The resulting increase …

The pathogenesis of pulmonary hypertension (PH) remains poorly understood.
Vasoconstriction, although likely to be a major factor in the disease, varies between patients …

Background—Pulmonary arterial hypertension is a progressive proliferative vasculopathy of
the small pulmonary arteries that is characterized by a primary failure of the endothelial nitric …

Rationale: Decreased nitric oxide (NO) is considered an important pathogenetic mechanism
in pulmonary arterial hypertension (PAH), but clear evidence is lacking. Objectives: We used …

Endothelium-derived NO is considered to be primarily an important determinant of vascular
tone and platelet activity; however, the modulation of myocardial metabolism by NO may be …

In the pulmonary vasculature, the mechanisms responsible for oxygen sensing and the
initiation of hypoxia-induced vasoconstriction and vascular remodeling are still unclear …

To examine the effect of chronic hypoxia on nitric oxide (NO) production and the amount of
the endothelial isoform of nitric oxide synthase (eNOS) in lungs of newborn piglets, studies …