Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans
ML Blitzer, E Loh, MA Roddy, JS Stamler… - Journal of the American …, 1996 - Elsevier
Objectives. This investigation sought to determine whether endothelium-derived nitric oxide
contributes to hypoxia-induced systemic vasodilation and pulmonary vasoconstriction in …
contributes to hypoxia-induced systemic vasodilation and pulmonary vasoconstriction in …
Nitrite signaling in pulmonary hypertension: mechanisms of bioactivation, signaling, and therapeutics
Significance: Pulmonary arterial hypertension (PAH) is a disorder characterized by
increased pulmonary vascular resistance and mean pulmonary artery pressure leading to …
increased pulmonary vascular resistance and mean pulmonary artery pressure leading to …
Nitric oxide deficiency and endothelial dysfunction in pulmonary arterial hypertension
JR Klinger, SH Abman, MT Gladwin - American journal of …, 2013 - atsjournals.org
Nitric oxide (NO) signaling plays a major role in modulating vascular tone and remodeling in
the pulmonary circulation, but its role in the pathogenesis of pulmonary vascular diseases is …
the pulmonary circulation, but its role in the pathogenesis of pulmonary vascular diseases is …
The role of the NO axis and its therapeutic implications in pulmonary arterial hypertension
ED Michelakis - The Role of Nitric Oxide in Heart Failure, 2004 - Springer
Abstract Pulmonary Arterial Hypertension (PAH) is a disease of the pulmonary vasculature
leading to vasoconstriction and remodeling of the pulmonary arteries. The resulting increase …
leading to vasoconstriction and remodeling of the pulmonary arteries. The resulting increase …
High expression of endothelial nitric oxide synthase in plexiform lesions of pulmonary hypertension
NA Mason, DR Springall, M Burke… - The Journal of …, 1998 - Wiley Online Library
The pathogenesis of pulmonary hypertension (PH) remains poorly understood.
Vasoconstriction, although likely to be a major factor in the disease, varies between patients …
Vasoconstriction, although likely to be a major factor in the disease, varies between patients …
Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase–dependent nitric oxide …
BS Zuckerbraun, S Shiva, E Ifedigbo, MA Mathier… - Circulation, 2010 - Am Heart Assoc
Background—Pulmonary arterial hypertension is a progressive proliferative vasculopathy of
the small pulmonary arteries that is characterized by a primary failure of the endothelial nitric …
the small pulmonary arteries that is characterized by a primary failure of the endothelial nitric …
Decreased exhaled nitric oxide in pulmonary arterial hypertension: response to bosentan therapy
RE Girgis, HC Champion, GB Diette… - American journal of …, 2005 - atsjournals.org
Rationale: Decreased nitric oxide (NO) is considered an important pathogenetic mechanism
in pulmonary arterial hypertension (PAH), but clear evidence is lacking. Objectives: We used …
in pulmonary arterial hypertension (PAH), but clear evidence is lacking. Objectives: We used …
Role of endothelium-derived nitric oxide in the regulation of cardiac oxygen metabolism: implications in health and disease
JN Trochu, JB Bouhour, G Kaley, TH Hintze - Circulation research, 2000 - Am Heart Assoc
Endothelium-derived NO is considered to be primarily an important determinant of vascular
tone and platelet activity; however, the modulation of myocardial metabolism by NO may be …
tone and platelet activity; however, the modulation of myocardial metabolism by NO may be …
Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature
R Paddenberg, B Ishaq… - … of Physiology-Lung …, 2003 - journals.physiology.org
In the pulmonary vasculature, the mechanisms responsible for oxygen sensing and the
initiation of hypoxia-induced vasoconstriction and vascular remodeling are still unclear …
initiation of hypoxia-induced vasoconstriction and vascular remodeling are still unclear …
Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs
CD Fike, MR Kaplowitz, CJ Thomas… - American Journal of …, 1998 - journals.physiology.org
To examine the effect of chronic hypoxia on nitric oxide (NO) production and the amount of
the endothelial isoform of nitric oxide synthase (eNOS) in lungs of newborn piglets, studies …
the endothelial isoform of nitric oxide synthase (eNOS) in lungs of newborn piglets, studies …