occur in patients with idiopathic PPH. 6, 7 Whether these cells are derived from the
endothelial progenitor cells obtained from the mobilization of bone marrow by growth factors …

Data are rapidly accumulating in support of the idea that circulating monocytes and/or
mononuclear fibrocytes are recruited to the pulmonary circulation of chronically hypoxic …

Chronic hypoxia caused by migration of native sea‐level dwellers to high altitude or chronic
lung disease leads to the development of increased pulmonary vascular resistance and …

Recent evidence suggests that endothelial dysfunction and pathology of pulmonary vascular
responses may serve as a precursor to smoking-associated emphysema. Although it is …

Rationale: Pulmonary arterial hypertension (PAH) is a proliferative arteriopathy associated
with glucose transporter-1 (Glut1) up-regulation and a glycolytic shift in lung metabolism …

Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary
vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and …

From the discovery of hypoxic pulmonary vasoconstriction, responses to hypoxia have been
considered as representative for the many alterations in lung vessels that occur in several …

Hypoxic pulmonary hypertension (PH) comprises a heterogeneous group of diseases
sharing the common feature of chronic hypoxia-induced pulmonary vascular remodeling …

The vascular endothelium synthesises, metabolises or converts a multitude of vasoactive
mediators, and plays a vital role in the regulation of pulmonary vascular resistance. Its role in …

This perspective highlights advances in the understanding of the role of cellular metabolism
in the pathogenesis of pulmonary hypertension. Insights gained in the past 20 years have …