IRS II (Invasive reperfusion study II) was a multicentre randomized trial comparing the
efficacy of a 2–5-min 30 U anistreplase intravenous injection with a 1 500 000 U 60-min …

Thrombolytic therapy is a practical, effective approach to the management of acute
myocardial infarction that is widely used in Europe today. Early European trials …

In acute myocardial infarction, myocardial salvage is dependent on rapid restoration of
blood flow. Pharmacologic (streptokinase, recombinant tissue-type plasminogen activator) …

Rescue thrombolysis appears to be safe and may be an alternative to angioplasty when
normal epicardial blood flow is not achieved after administration of thrombolytic therapy in …

Survival of patients with acute transmural infarction is largely related to the size of the
myocardial infarction. The goal of thrombolytic therapy in acute myocardial infarction is …

Background The recent international GUSTO trial of 41 021 patients with acute myocardial
infarction demonstrated improved 90-mm infarct related artery patency as well as reduced …

The efficacy of intravenous (iv) thrombolytic therapy has not been firmly established in
comparison with the intracoronary (ic) route of administration. In a randomized trial of 28 …

Reperfusion of acute myocardial infarction has become the standard of management during
the first few hours. Cost per year of life saved is one measure of the effectiveness of …

A computer model was developed to analyze the costs to Medicare and the potential
procedure volume associated with alternative strategies for treatment of acute myocardial …

Figure 1:(A) Mortality curves in GUSTO 1 by thrombolytic strategy assignment. For
streptokinase (SK) the parentheses indicate the heparin strategy, intravenous (iv) or …