PTEN Is Inversely Correlated With the Cell Survival Factor Akt/PKB and Is Inactivated Via Multiple Mechanisms in Haematological Malignancies
PLM Dahia, RCT Aguiar, J Alberta… - Human molecular …, 1999 - academic.oup.com
PTEN is a novel tumour suppressor gene that encodes a dual-specificity phosphatase with
homology to adhesion molecules tensin and auxillin. It recently has been suggested that …
homology to adhesion molecules tensin and auxillin. It recently has been suggested that …
PTEN: life as a tumor suppressor
L Simpson, R Parsons - Experimental cell research, 2001 - Elsevier
PTEN, a tumor suppressor located at chromosome 10q23, is mutated in a variety of sporadic
cancers and in two autosomal dominant hamartoma syndromes. PTEN is a phosphatase …
cancers and in two autosomal dominant hamartoma syndromes. PTEN is a phosphatase …
Discovery of the PTEN tumor suppressor and its connection to the PI3K and AKT oncogenes
R Parsons - Cold Spring Harbor Perspectives in …, 2020 - perspectivesinmedicine.cshlp.org
PTEN (phosphatase and tensin homolog on chromosome 10) was discovered over 20 years
ago in 1997 and linked to the phosphatidylinositol 3-kinase (PI3K) and AKT oncogenes the …
ago in 1997 and linked to the phosphatidylinositol 3-kinase (PI3K) and AKT oncogenes the …
[HTML][HTML] The PTEN tumor suppressor gene and its role in lymphoma pathogenesis
X Wang, H Huang, KH Young - Aging (Albany NY), 2015 - ncbi.nlm.nih.gov
The phosphatase and tensin homolog gene PTEN is one of the most frequently mutated
tumor suppressor genes in human cancer. Loss of PTEN function occurs in a variety of …
tumor suppressor genes in human cancer. Loss of PTEN function occurs in a variety of …
PTEN regulatory functions in tumor suppression and cell biology.
EC Chu, AS Tarnawski - Medical science monitor: international …, 2004 - europepmc.org
PTEN is a dual-specificity phosphatase with both protein phosphatase and lipid
phosphatase activity. PTEN is the first phosphatase identified as a tumor suppressor. Not …
phosphatase activity. PTEN is the first phosphatase identified as a tumor suppressor. Not …
[HTML][HTML] Direct identification of PTEN phosphorylation sites
The PTEN tumor suppressor gene encodes a phosphatidylinositol 3′-phosphatase that is
inactivated in a high percentage of human tumors, particularly glioblastoma, melanoma, and …
inactivated in a high percentage of human tumors, particularly glioblastoma, melanoma, and …
PTEN: from pathology to biology
ML Sulis, R Parsons - Trends in cell biology, 2003 - cell.com
The PTEN tumour suppressor gene is mutated frequently in many malignancies and its
importance in the development of cancer is probably underestimated. As the primary …
importance in the development of cancer is probably underestimated. As the primary …
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways …
The tumour suppressor protein, PTEN (phosphatase and tensin homolog deleted on
chromosome 10), is a phosphatase that can dephosphorylate tyrosine-containing peptides …
chromosome 10), is a phosphatase that can dephosphorylate tyrosine-containing peptides …
The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling
F Vazquez, WR Sellers - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2000 - Elsevier
PTEN/MMAC-1/TEP-1 (referred to hereafter as PTEN) is a tumor suppressor gene that maps
to the 10q23 interval, a chromosomal region frequented by loss-of-heterozygosity (LOH) …
to the 10q23 interval, a chromosomal region frequented by loss-of-heterozygosity (LOH) …
[HTML][HTML] Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases
J Liliental, SY Moon, R Lesche, R Mamillapalli, D Li… - Current Biology, 2000 - cell.com
Pten (Phosphatase and tensin homolog deleted on chromosome 10) is a recently identified
tumor suppressor gene which is deleted or mutated in a variety of primary human cancers …
tumor suppressor gene which is deleted or mutated in a variety of primary human cancers …