High-linear-energy-transfer (LET) radiation is more lethal than similar doses of low-LET
radiation types, probably a result of the condensed energy deposition pattern of high-LET …

DNA double-strand breaks (DSBs) are a serious threat to genome stability and cell viability.
Although biological effects of low levels of radiation are not clear, the risks of low-dose …

Biological effects of high-LET (linear energy transfer) radiation have received increasing
attention, particularly in the context of more efficient radiotherapy and space exploration …

Cells react differently to clustered and dispersed DNA double strand breaks (DSB). Little is
known about the initial reaction to simultaneous induction of DSBs with different …

Cellular lesions (eg DSBs) are induced into DNA upon exposure to radiation, with DSB
complexity increasing with radiation ionization density. Using M059K and M059J human …

Low-and high-linear energy transfer (LET) ionising radiation are effective cancer therapies,
but produce structurally different forms of DNA damage. Isolated DNA damage is repaired …

Clustered DNA damage sites, in which two or more lesions are formed within a few helical
turns of the DNA after passage of a single radiation track, are signatures of DNA …

Photons, such as X-or γ-rays, induce DNA damage (distributed throughout the nucleus) as a
result of low-density energy deposition. In contrast, particle irradiation with high linear …

The superior dose distribution of particle radiation compared to photon radiation makes it a
promising therapy for the treatment of tumors. However, the cellular responses to particle …

Abstract Hu, B., Han, W., Wu, L., Feng, H., Liu, X., Zhang, L., Xu, A., Hei, T K. and Yu, Z. In
Situ Visualization of DSBs to Assess the Extranuclear/Extracellular Effects Induced by Low …