Elevated thyroid manganese reduces thyroid iodine to induce hypothyroidism in mice, but not rats, lacking SLC30A10 transporter
S Hutchens, A Melkote, T Jursa, W Shawlot… - Metallomics, 2024 - academic.oup.com
Elevated manganese (Mn) accumulates in the brain and induces neurotoxicity. SLC30A10 is
a Mn efflux transporter that controls body Mn levels. We previously reported that full-body …
a Mn efflux transporter that controls body Mn levels. We previously reported that full-body …
Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice
S Hutchens, C Liu, T Jursa, W Shawlot… - Journal of Biological …, 2017 - ASBMB
Manganese is an essential metal that becomes toxic at elevated levels. Loss-of-function
mutations in SLC30A10, a cell-surface-localized manganese efflux transporter, cause a …
mutations in SLC30A10, a cell-surface-localized manganese efflux transporter, cause a …
Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production
C Liu, S Hutchens, T Jursa, W Shawlot… - Journal of Biological …, 2017 - ASBMB
SLC30A10 and SLC39A14 are manganese efflux and influx transporters, respectively. Loss-
of-function mutations in genes encoding either transporter induce hereditary manganese …
of-function mutations in genes encoding either transporter induce hereditary manganese …
Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice
Y Xin, H Gao, J Wang, Y Qiang, MU Imam, Y Li, J Wang… - Cell discovery, 2017 - nature.com
SLC39A14 (also known as ZIP14), a member of the SLC39A transmembrane metal
transporter family, has been reported to mediate the cellular uptake of iron and zinc …
transporter family, has been reported to mediate the cellular uptake of iron and zinc …
SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity
CA Taylor, S Hutchens, C Liu, T Jursa… - Journal of Biological …, 2019 - ASBMB
The essential metal manganese becomes neurotoxic at elevated levels. Yet, the
mechanisms by which brain manganese homeostasis is regulated are unclear. Loss-of …
mechanisms by which brain manganese homeostasis is regulated are unclear. Loss-of …
Metal-ion transporter SLC39A8 is required for brain manganese uptake and accumulation
Q Liu, S Jenkitkasemwong, TA Prami… - Journal of Biological …, 2023 - ASBMB
Manganese (Mn) is an essential nutrient, but is toxic in excess. Whole-body Mn levels are
regulated in part by the metal-ion influx transporter SLC39A8, which plays an essential role …
regulated in part by the metal-ion influx transporter SLC39A8, which plays an essential role …
Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity
CJ Mercadante, M Prajapati… - The Journal of …, 2019 - Am Soc Clin Investig
Manganese (Mn), an essential metal and nutrient, is toxic in excess. Toxicity classically
results from inhalational exposures in individuals who work in industrial settings. The first …
results from inhalational exposures in individuals who work in industrial settings. The first …
Loss of SLC30A10 manganese transporter alters expression of neurotransmission genes and activates hypoxia-inducible factor signaling in mice
A Warden, RD Mayfield, KC Gurol, S Hutchens… - Metallomics, 2024 - academic.oup.com
The essential metal manganese (Mn) induces neuromotor disease at elevated levels. The
manganese efflux transporter SLC30A10 regulates brain Mn levels. Homozygous loss-of …
manganese efflux transporter SLC30A10 regulates brain Mn levels. Homozygous loss-of …
Up-regulation of the manganese transporter SLC30A10 by hypoxia-inducible factors defines a homeostatic response to manganese toxicity
Manganese (Mn) is an essential metal that induces incurable parkinsonism at elevated
levels. However, unlike other essential metals, mechanisms that regulate mammalian Mn …
levels. However, unlike other essential metals, mechanisms that regulate mammalian Mn …
SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice
S Jenkitkasemwong, A Akinyode… - Proceedings of the …, 2018 - National Acad Sciences
Solute carrier family 39, member 14 (SLC39A14) is a transmembrane transporter that can
mediate the cellular uptake of zinc, iron, and manganese (Mn). Studies of Slc39a14 …
mediate the cellular uptake of zinc, iron, and manganese (Mn). Studies of Slc39a14 …