Genetic manipulation is a powerful tool to establish the causal relationship between a
genetic lesion and a particular pathological phenotype. The rise of CRISPR/Cas9 genome …

The pinnacle of four decades of research, induced pluripotent stem cells (iPSCs), and
genome editing with the advent of clustered, regularly interspaced, short palindromic …

The recent development of the CRISPR/Cas9 system as an efficient and accessible
programmable genome‐editing tool has revolutionized basic science research …

The CRISPR-Cas9 system has emerged as a powerful and efficient tool for genome editing.
An important drawback of the CRISPR-Cas9 system is the constitutive endonuclease activity …

Targeted nucleases are widely used as tools for genome editing. Two years ago the
clustered regularly interspaced short palindromic repeat (CRISPR)-associated Cas9 …

CRISPR/Cas9 technology has evolved as the most powerful approach to generate genetic
models both for fundamental and preclinical research. Despite its apparent simplicity, the …

Based on the tremendous progress of the understanding on the CRISPR‐Cas systems, the
application CRISPR/Cas technology has been extended into increasing scenarios in …

Genome-editing involves the insertion, deletion, or replacement of DNA in the genome of a
living organism using" molecular scissors." Traditional genome editing with engineered …

Abstract CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology
has emerged as a powerful technology for genome editing and is now widely used in basic …

Background: Induced pluripotent stem cells hold tremendous potential for biological and
therapeutic applications. The development of efficient technologies for targeted genome …