The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Older adults are more susceptible to viral and bacterial infection, and experience higher
incidence and severity of infectious diseases. Although vaccination is the most logical …

Aging is associated with declines in immune system function, or 'immunosenescence',
leading to progressive deterioration in both innate and adaptive immunity. These changes …

Successful vaccination of the elderly against important infectious pathogens that cause high
morbidity and mortality represents a growing public health priority. Building on the theme of …

The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …

In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly
because of the adaptive immune system's inability to generate protective immunity. The age …

Immunosenescence contributes to a decreased capacity of the immune system to respond
effectively to infections or vaccines in the elderly. The full extent of the biological changes …

Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …

With a falling birth rate and increasing life expectancy we are experiencing dramatic
demographic changes that result in an ever ageing population. Aging is accompanied by …

An age-related decline in immune responses in the elderly results in greater susceptibility to
infection and reduced responses to vaccination. This decline in immune function affects both …