Lysine-specific demethylase 5A (KDM5A), an enzyme that removes activating H3K4 di-and
trimethylation marks, plays critical roles in controlling transcription and chromatin …

The histone lysine demethylase KDM4 subfamily, comprised of four members (A, B, C, and
D), play critical roles in controlling transcription, chromatin architecture and cellular …

Histone lysine demethylases (KDMs) comprise a large class of enzymes that catalyze site‐
specific demethylation of lysine residues on histones and other proteins. They play critical …

Histone methylation is important in the regulation of genes expression, and thus its
dysregulation has been observed in various cancers. KDM5 enzymes are capable of …

KDM4 histone demethylases catalyze the removal of methyl marks from histone lysine
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …

Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …

The histone lysine demethylase KDM5B regulates gene transcription and cell differentiation
and is implicated in carcinogenesis. It contains multiple conserved chromatin-associated …

Histone posttranslational modifications are important components of epigenetic regulation.
One extensively studied modification is the methylation of lysine residues. These …

Abstract The H3K4 demethylase KDM5B is overexpressed in multiple cancer types, and
elevated expression levels of KDM5B is associated with decreased survival. However, the …

Invasive growth and apoptosis resistance of breast cancer cells are associated with
metastasis and disease relapse. Here we identified that the lysine-specific demethylase …