CD40L, a member of the tumor necrosis factor family of ligands, plays a major role in
immune responses via its receptor, CD40. Recently, CD40L has been detected on the …

Abstract CD40 ligand (CD40L), identified as a costimulatory molecule expressed on T cells,
is also expressed and functional on platelets. We investigated the thrombotic and …

CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF
receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an …

It was originally thought that the critical role of the CD40 ligand (CD40L) in normal and
inflammatory immune responses was mainly mediated through its interaction with the classic …

Objective—Beyond their eminent role in hemostasis and thrombosis, platelets are
recognized as mediators of inflammation. Platelet cluster of differentiation 40 (CD40) ligand …

The CD40 ligand (CD40L)-CD40 dyad can ignite proinflammatory and procoagulatory
activities of the vascular endothelium in the pathogenesis and progression of …

Abstract CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the
cytokine TNF-α, was originally identified on stimulated CD4+ T cells,,, and later on …

Recently, we have demonstrated that human platelets carry preformed CD40 ligand
(CD154) molecules, which rapidly appear on the platelet surface following stimulation by …

Increasing amounts of evidence support the involvement of inflammation and immunity in
atherogenesis,,, but mediators of communication between the major cell types in …

Atherosclerosis is a degenerative inflammatory disease of the vascular system. Endothelial
cells (ECs), smooth muscle cells, and macrophages, key elements in atherosclerosis, all …