Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received
considerable attention due to its role in human cancers. Observational and randomized …

Mortality in patients with advanced colorectal cancer (CRC) remains high. Epidemiologic
studies show that individuals taking nonselective, nonsteroidal anti-inflammatory drugs …

Abstract Cyclooxygenase‐2 (COX‐2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers. A …

Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms:
hereditary, sporadic and colitis-associated CRC. A large body of evidence indicates that …

Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …

The cyclooxygenase-2 (COX-2) enzyme has a fundamental role in the carcinogenesis of
colorectal cancer. The anticarcinogenic mechanisms of NSAIDs are not completely …

Population-based studies have established that long-term intake of non-steroidal anti-
inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of …

Abstract Cyclooxygenase2 (COX-2), an inducible prostaglandin G/H synthase, is
overexpressed in several human cancers. Here, the potential utility of selective COX-2 …

Cyclooxygenase (COX), the key regulatory enzyme for prostaglandin synthesis, is
transcribed from two distinct genes. COX-1 is expressed constitutively in most tissues …

Abstract Cyclooxygenase-2 (COX-2) is an inducible enzyme that regulates prostaglandin
synthesis and is overexpressed at sites of inflammation and in several epithelial cancers …