The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin
(PG) biosynthesis. Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the …

Cyclooxygenase-2 (COX-2) is being intensively evaluated as a pharmacologic target for
both the prevention and treatment of cancer. Aberrant COX-2 expression was initially …

Abstract Cyclooxygenase-1 and-2 (COX-1/2) catalyze the initial step in the formation of
prostaglandins. Very recently their role in carcinogenesis has become more evident. They …

Two events in the last decade have set the stage for the large-scale clinical testing of
chemopreventive agents for colorectal cancer in people at low to moderate risk for this …

Abstract Cyclooxygenase 2 (COX-2), also called prostaglandin endoperoxide synthase 2, is
involved in colorectal tumor development. This review deals with particular questions raised …

During recent years, multidisciplinary studies in epidemiology and molecular biology, as
well as preclinical studies, have contributed much to our understanding of the etiology of …

Abstract Selective cyclooxygenase (COX)-2 inhibitors (coxibs) were developed as one of the
anti-inflammatory drugs to avoid the various side effects of non-steroidal anti-inflammatory …

The two isoforms cyclooxygenase-1 and-2 catalyze the initial step in the formation of
prostaglandins in a variety of pathophysiological processes. More recently their role in …

Chronic inflammation is a tissue-specific process implicated in several diseases of an aging
population, including cancer, cardiovascular disease, and arthritis. Cyclooxygenase-2 (COX …

Background Epidemiologic and laboratory investigations suggest that aspirin and other
nonsteroidal anti-inflammatory drugs (NSAIDs) have chemopreventive effects against colon …