Colorectal cancer is a major cause of mortality and whilst up to 80% of sporadic colorectal
tumours are considered preventable, trends toward increasing obesity suggest the potential …

Epidemiological studies have demonstrated that nonsteroidal anti-inflammatory drugs
(NSAIDs), known to inhibit cyclooxygenase (COX), reduce the risk of colorectal cancer. COX …

▪ Abstract Disease prevention is one area that both public and governmental agencies
strongly support owing to its potential for an improved lifestyle and a reduction in health care …

Non‐steroidal anti‐inflammatory drugs (NSAIDs) and specific inhibitors of cyclooxygenase
(COX)‐2, are therapeutic groups widely used for the treatment of pain, inflammation and …

Despite recent improvements in chemotherapy and radiation therapy in cancer management
with the addition of biological agents, novel treatment approaches are needed to further …

The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …

Cyclooxygenase (COX) inhibitors are being developed as potential agents for the
prevention and treatment of cancer after a century of widespread use for inflammation, fever …

Carcinoma of the colon or rectum represents one of the most common malignancies
worldwide with a higher prevalence in industrialized regions. Epidemiologic studies of …

Early experiments performed during 1980s and 1990s using carcinogen-induced rat
intestinal tumor models demonstrated the inhibitory effects of non-steroidal anti-inflammatory …

AIM: Recent clinical epidemiological studies have demonstrated the preventive effect of non-
steroidal anti-inflammatory drugs (NSAIDs) against colorectal cancer. The underlying …