Bit by bit, over the last few decades, functional genomic tools have been piecing together the
molecular puzzle driving tumorigenesis in human patients. Nevertheless, our understanding …

Simple Summary High-throughput CRISPR screening provides an unbiased way for
functional genomic studies in hematological malignancies. This approach has been used to …

Hematological malignancies (HM) are a group of neoplastic diseases that are usually
heterogenous in nature due to the complex underlying genetic aberrations in which …

Highlights•CRISPR/Cas9 overcomes limitations of earlier targeted nuclease-mediated
methods.•CRISPR/Cas9 allows for insertions/deletions of multiple alleles in a single …

Background: Functional genomic screens elegantly increase our understanding of biology of
leukemias. So far, CRISPR/Cas9 screens are widely performed in cell lines and in …

Highlights•CRISPR/Cas9 has been widely used for the identification of potential therapeutic
targets in cancer.•Several potential targets such as CD38, CXCR2, MASTL and RBX2 have …

Advances in translational research are often driven by new technologies. The advent of
microarrays, next-generation sequencing, proteomics, and RNAi have led to breakthroughs …

The CRISPR genome editing technology has revolutionized the way gene function is
studied. Genome editing can be achieved in single genes or for thousands of genes …

The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-
associated protein 9 (Cas9)(CRISPR/Cas9) system is a powerful tool that enables precise …

The discovery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and
CRISPR-associated protein 9 (Cas9) technology has revolutionized field of cancer …