Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats

R Taliyan, PL Sharma - Inflammopharmacology, 2012 - Springer
Introduction Diabetes-induced neuropathic pain is recognized as one of the most difficult
type of pain to treat and conventional analgesics are well known to be partially effective or …

Effect of dipyrone and thalidomide alone and in combination on STZ-induced diabetic neuropathic pain

N Chauhan, R Taliyan, PL Sharma - Naunyn-Schmiedeberg's archives of …, 2012 - Springer
Diabetic neuropathy is recognized as one of the most common complications of chronic
diabetes, but its pathophysiological mechanism is complex and yet to be completely …

Pyridoxamine alleviates mechanical allodynia by suppressing the spinal receptor for advanced glycation end product-nuclear factor-κ B/extracellular signal-regulated …

X Zhang, L Xu, W Chen, X Yu, L Shen… - Molecular …, 2020 - journals.sagepub.com
Diabetic neuropathic pain is a common complication of diabetes mellitus and requires a
substantial amount of societal resources. Pyridoxamine is an inhibitor of advanced glycation …

Tanshinone IIA attenuates diabetic peripheral neuropathic pain in experimental rats via inhibiting inflammation

B Zhang, Y Yu, G Aori, Q Wang, D Kong… - Evidence‐Based …, 2018 - Wiley Online Library
Diabetic peripheral neuropathic pain (DPNP) is a common and intractable complication of
diabetes. Conventional therapies are always not ideal; development of novel drugs is still …

[HTML][HTML] Neuroprotective effect of tanshinone IIA against neuropathic pain in diabetic rats through the Nrf2/ARE and NF-κB signaling pathways

FB Feng, HY Qiu - The Kaohsiung journal of medical sciences, 2018 - Elsevier
The study aims to investigate whether tanshinone (TSN) IIA affects diabetic neuropathic pain
(DNP) via the Nrf2/AR and NF-κB signaling pathways. Rats were randomly assigned into …

[HTML][HTML] Evaluating the Antihyperalgesic Potential of Sildenafil–Metformin Combination and Its Impact on Biochemical Markers in Alloxan-Induced Diabetic …

C Pușcașu, S Negreș, CE Zbârcea, A Ungurianu… - Pharmaceuticals, 2024 - mdpi.com
(1) Background: Globally, about 600 million people are afflicted with diabetes, and one of its
most prevalent complications is neuropathy, a debilitating condition. At the present time, the …

Telmisartan inhibits hyperalgesia and inflammatory progression in a diabetic neuropathic pain model of Wistar rats

SS Al-Rejaie, HM Abuohashish, MM Ahmed… - Neurosciences …, 2015 - nsj.org.sa
Objective: To evaluate the potential therapeutic value of telmisartan (TMT) against diabetic
neuropathy (DN) and associated pain in Wistar rats. Methods: Peripheral DN was induced …

Ginger extract and its compound, 6-shogaol, attenuates painful diabetic neuropathy in mice via reducing TRPV1 and NMDAR2B expressions in the spinal cord

FA Fajrin, AE Nugroho, A Nurrochmad… - Journal of …, 2020 - Elsevier
Ethnopharmacological relevance In silico data revealed that the active compound of ginger
(Zingiber officinale Roscoe), 6-shogaol, has strong affinity toward transient receptor potential …

Protective Effect and Potential Mechanism of Ginkgo biloba Extract EGb 761 on STZ‐induced Neuropathic Pain in Rats

R Taliyan, PL Sharma - Phytotherapy Research, 2012 - Wiley Online Library
Diabetes induced neuropathic pain is recognized as one of the most difficult types of pain to
treat with conventional analgaesics. EGb 761 is a standardized extract of Ginkgo biloba that …

Lycopene attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain

A Kuhad, S Sharma, K Chopra - European Journal of Pain, 2008 - Elsevier
Diabetic neuropathic pain, an important microvascular complication of diabetes mellitus is
recognized as one of the most difficult types of pain to treat. The development of tolerance …