The rewarding effect of cocaine as reflected by the development of conditioned place
preference was examined in C57BL/6J and 129/J mice. Cocaine was administered in a …

Rationale The place conditioning procedure is increasingly used to study relapse in drug
seeking in mice. However, the retention course of drug-induced place preference has not …

Previous studies have demonstrated that rats showing a strong locomotor response to a
novel environment have a greater locomotor response to psychostimulant drugs and more …

Rationale: In previous comparisons with C57BL/6J mice, DBA/2J mice have been
characterized as” hyporesponsive” to cocaine's rewarding effect in the conditioned place …

The conditioned place preference paradigm was used to investigate the reinforcing
properties of cocaine. Rats were injected (ip) with cocaine hydrochloride (0.625–20 mg/kg) …

An unbiased place preference conditioning procedure was used to determine whether the
repeated administration of cocaine results in sensitization to its conditioned rewarding …

To explore sex differences in reinstatement of conditioned place preference, we subjected
intact male and female Long Evans rats to an extended conditioned place preference (CPP) …

The aim of the present study was to determine if pre-exposure to high doses of cocaine can
subsequently alter the rewarding effects of this drug. Adult male mice received a …

Cocaine has repeatedly been shown to produce conditioned place preference (CPP) in the
rat. The present study employed the heterogenous N/Nih rat stock to produce a selectively …

Rats allowed extended access to cocaine self-administration develop a number of
symptoms of addiction, such as greater susceptibility to drug-induced relapse. Using the …