Human papillomavirus type 16 E7 oncoprotein expressed in peripheral epithelium tolerizes E7-directed cytotoxic T-lymphocyte precursors restricted through human …
T Doan, K Herd, M Street, G Bryson… - Journal of …, 1999 - Am Soc Microbiol
Mice which coexpress human papillomavirus type 16 E7 and HLA A2. 1 in peripheral
squamous epithelium and thymic cortical epithelium are tolerant at the cytotoxic T …
squamous epithelium and thymic cortical epithelium are tolerant at the cytotoxic T …
Mice expressing the E7 oncogene of HPV16 in epithelium show central tolerance, and evidence of peripheral anergising tolerance, to E7-encoded cytotoxic T …
T Doan, M Chambers, M Street, GJP Fernando, K Herd… - Virology, 1998 - Elsevier
In order to derive mice which expressed both the E7 open reading frame transgene of
human papillomavirus type 16 in skin and MHC class 1 restriction elements for several E7 …
human papillomavirus type 16 in skin and MHC class 1 restriction elements for several E7 …
Nonspecific Down-Regulation of CD8+T-Cell Responses in Mice Expressing Human Papillomavirus Type 16 E7 Oncoprotein from the Keratin-14 Promoter
RW Tindle, K Herd, T Doan, G Bryson… - Journal of …, 2001 - Am Soc Microbiol
The E7 oncoprotein of human papillomavirus 16 (HPV16) transforms basal and suprabasal
cervical epithelial cells and is a tumor-specific antigen in cervical carcinoma, to which …
cervical epithelial cells and is a tumor-specific antigen in cervical carcinoma, to which …
E7 oncoprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B-or Th-repertoires or on the immune response …
A line of FVB (H-2q) mice transgenic for the E6/E7 open reading frames of Human
Papillomavirus type 16 driven from the α-A crystallin promoter expresses E7 mRNA in lens …
Papillomavirus type 16 driven from the α-A crystallin promoter expresses E7 mRNA in lens …
Peripheral tolerance to human papillomavirus E7 oncoprotein occurs by cross-tolerization, is largely Th-2-independent, and is broken by dendritic cell immunization
T Doan, KA Herd, PF Lambert, GJP Fernando… - Cancer research, 2000 - AACR
The E7 oncoprotein of human papillomavirus 16 functions as a tumor-specific antigen in
transformed epithelial cells of the uterine cervix to which immunotherapeutic strategies …
transformed epithelial cells of the uterine cervix to which immunotherapeutic strategies …
Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16
I Melero, MC Singhal, P McGowan, HS Haugen… - Journal of …, 1997 - Am Soc Microbiol
Certain human papillomaviruses (HPV) have been implicated in the etiology of cervical
malignancies, and the E7 and E6 gene products of HPV type 16 are frequently expressed in …
malignancies, and the E7 and E6 gene products of HPV type 16 are frequently expressed in …
HPV16-E7-specific activated CD8 T cells in E7 transgenic skin and skin grafts
Human papillomavirus (HPV) 16 E7 (E7) protein expression in skin promotes epithelial
hyperproliferation and transformation to malignancy. Grafts of murine skin expressing E7 …
hyperproliferation and transformation to malignancy. Grafts of murine skin expressing E7 …
E7-specific cytotoxic T cell tolerance in HPV-transgenic mice
A Borchers, J Braspenning, J Meijer, W Osen… - Archives of …, 1999 - Springer
The “high-risk” human papillomavirus type 16 (HPV 16) is associated with the development
of cervical cancer. Although the viral gene products E6 and E7 are constitutively expressed …
of cervical cancer. Although the viral gene products E6 and E7 are constitutively expressed …
Development of a DNA vaccine targeting human papillomavirus type 16 oncoprotein E6
Human papillomavirus (HPV), particularly type 16 (HPV-16), is present in more than 99% of
cervical cancers. The HPV oncoproteins E6 and E7 are constantly expressed and therefore …
cervical cancers. The HPV oncoproteins E6 and E7 are constantly expressed and therefore …
Immunological responses in human papillomavirus 16 E6/E7-transgenic mice to E7 protein correlate with the presence of skin disease
The human papillomavirus (HPV) oncogenes, E6 and E7, are believed to contribute to the
development of cervical cancers in women infected with certain HPV genotypes, most …
development of cervical cancers in women infected with certain HPV genotypes, most …