Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels mediate
pacemaker currents in the atrium. The microRNA (miR) families miR-1 and miR-133 regulate …

Background We compared cardiac electrophysiological indicators and regional expression
levels of cardiac hyperpolarization-activated cyclic nucleotide-gated (HCN) channels …

Background The sinus node (SN) is the primary pacemaker of the heart. SN myocytes
possess distinctive action potential morphology with spontaneous diastolic depolarization …

The expression of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel
isoforms varies among species, cardiac tissues, developmental stages, and disease …

Background: Atrial fibrillation (AF) begets AF in part due to atrial remodeling, the molecular
mechanisms of which have not been completely elucidated. This study was conducted to …

BACKGROUND: MicroRNAs are important regulators of gene expression, including those
involving electrical remodeling in atrial fibrillation (AF). Recently, KCNN3, the gene that …

BACKGROUND: Atrial fibrillation (AF) is associated with increased inward-rectifier current
activity that may stabilize atrial rotors maintaining the arrhythmia. Left atrial (LA) structures …

Background The potential mechanisms of microRNA-1 (miR-1) in the electrical remodeling
of atrial fibrillation remain unclear. The purpose of this study was to evaluate the effects of …

Objective: To investigate the changes in expression profile of circulating microRNAs
(miRNAs) and the regulatory effect of atrial fibrilation (AF)-related miRNAs on ion channels …

Background: The hyperpolarization-activated cation current I f contributes significantly to
sinoatrial node pacemaker function and possibly to ectopic arrhythmogenesis. Little is …