We investigated immunopathogenic roles for apoptosis in acute murine silicosis.
Intratracheal silica instillation induced pulmonary inflammation and enlarged thoracic lymph …

Long-term exposure to crystalline silica particles leads to silicosis characterized by
persistent inflammation and progressive fibrosis in the lung. So far, there is no specific …

Silica is utilized extensively in industrial and commercial applications as a chemical raw
material, increasing its exposure and hazardous potential to populations, with silicosis …

Silicosis is an occupational lung disease with no effective treatment. We hypothesized that
dasatinib, a tyrosine kinase inhibitor, might exhibit therapeutic efficacy in silica-induced …

Environmental exposure to crystalline silica (CS) can lead to silicosis. Alveolar
macrophages (AMs) play a crucial role in the pathogenesis of silicosis. Previously, we …

“Silica” refers to crystalline particles formed by the combination of silicon with oxygen.
Inhalation of silica particles promotes the development of pulmonary fibrosis that over …

Although silica-induced fibrosis and inflammation occurs independently of T, B, NK T, and
NK cells, lymphocytes regulate inflammation via modulation of the Nlrp3 inflammasome. The …

The inflammation and fibrosis induced by silica dust are considered to be substantial
responses in silicosis progression. Interleukin-1 beta (IL-1β) plays an important role in silica …

Occupational exposure to crystalline silica (CS) particles leads to silicosis, which is
characterized by chronic inflammation and abnormal tissue repair. Alveolar macrophages …

Numerous investigations have been conducted to elucidate mechanisms involved in the
initiation and progression of silicosis. However, most of these studies involved bolus …