Osteoarthritis (OA) is a major clinical problem across the world, in part due to the lack of
disease-modifying drugs resulting, to a significant degree, from our incomplete …

Abstract Purpose of Review Epigenomics has emerged as a key player in our rapidly
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …

Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors
are strongly associated with its development; however, recently it has been observed that …

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Introduction Osteoarthritis (OA) is a chronic musculoskeletal disease characterized by
progressive loss of joint function. Historically, it has been characterized as a disease caused …

Osteoarthritis (OA) is a complicated disease with both hereditary and environmental causes.
Despite an increase in reports of possible OA risk loci, it has become clear that genetics is …

The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being
obesity, age, environmental variables, and genetic predisposition. The available evidence …

Osteoarthritis (OA) is the most common type of arthritis and no longer is considered as an
absolute consequence of joint mechanical use (wear and tear); rather recent data …

The pathogenesis of osteoarthritis (OA) involves cartilage degradation, synovial
inflammation, subchondral bone sclerosis, degeneration of ligaments and meniscus, and …

Osteoarthritis (OA) is a complex multifactorial disease with a strong genetic component.
Several studies have suggested or identified epigenetic events that may play a role in OA …