Telomerase plays a pivotal role in the pathology of aging and cancer by maintaining
genome integrity, controlling cell proliferation, and regulating tissue homeostasis …

Telomerase reverse transcriptase (TERT) is the catalytic component of telomerase,
especially the rate-limiting determinant of telomerase activity. So far, TERT has been …

Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase
and plays important roles in human cancers. Aberrant expression of hTERT is closely …

Abnormal activation of telomerase occurs in most cancer types, which facilitates escaping
from cell senescence. As the key component of telomerase, telomerase reverse …

Telomerase, an RNA-dependent DNA polymerase with telomerase reverse transcriptase
(TERT) as the catalytic component, is silent due to the tight repression of the TERT gene in …

Chromosome-shortening is characteristic of normal cells, and is known as the end
replication problem. Telomerase is the enzyme responsible for extending the ends of the …

Background Limitless self-renewal is one of the hallmarks of cancer and is attained by
telomere maintenance, essentially through telomerase (h TERT) activation. Transcriptional …

Telomerase, regulated primarily by the transcription of its catalytic subunit telomerase
reverse transcriptase (TERT), is critical for controlling cell proliferation and tissue …

Telomerase reverse transcriptase (TERT), a catalytic subunit of telomerase, has been
demonstrated to exert a reverse transcriptase function when combined with telomerase RNA …

Telomerase activity is dependent on the expression of 2 main core component genes,
hTERT, which encodes the catalytic component and hTR (also called TERC), which …