Cancer results from the acquisition of somatic alterations in a microevolutionary process that
typically occurs over many years, much of which is occult. Understanding the evolutionary …

Populations of tumour cells display remarkable variability in almost every discernable
phenotypic trait, including clinically important phenotypes such as ability to seed metastases …

Cancer is a disease reliant on the generation of mutations and the subsequent selection of
those subpopulations endowed with the greatest fitness advantage. Beginning with a …

Analogous to life on earth, tumor cells evolve through space and time and adapt to different
micro-environmental conditions. As a result, tumors are composed of millions of genetically …

Recent technologic advances have permitted higher resolution and more rapid analysis of
individual cancer genomes at the single-nucleotide level. Such advances have shown …

Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …

Cancer patients die primarily due to disease recurrence after transient treatment responses.
The emergence of therapy‐resistant escape variants is fuelled by intra‐tumour …

To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Recent studies have shown that intratumor heterogeneity contributes to drug resistance in
advanced disease. Intratumor heterogeneity may foster the selection of a resistant subclone …

Abstract Analysis of spatial and temporal genetic heterogeneity in human cancers has
revealed that somatic cancer evolution in most cancers is not a simple linear process …