Cell-mediated cytotoxicity plays an important role in the clearance of noncytopathic viruses
from infected tissues. Perforin-dependent cytotoxic mechanisms have been noted to play an …

About 50% of cervical cancers are associated with human papillomavirus type 16 (HPV‐16),
and since the HPV‐16 E6 and E7 oncoproteins are constitutively expressed in the tumor …

Mice which coexpress human papillomavirus type 16 E7 and HLA A2. 1 in peripheral
squamous epithelium and thymic cortical epithelium are tolerant at the cytotoxic T …

Adhesions of lymphocytes, among themselves or with other cell types, are necessary for
most steps in immune responses including both induction and effector phases. Among …

Induction of cytotoxic T lymphocyte (CTL) responses is an important defense mechanism
against infectious agents, specifically viruses. In the present investigation we employed a …

The generation of knockout mice demonstrated that CD4+, but not CD8+, T cells were
essential for the rejection of allografted skin or heart, presumably because these targets …

We have used a mouse model that utilizes the exclusively epithelial nature of human
papillomavirus (HPV) infections to investigate the in vivo immune response to the E7 protein …

Interleukin-10 (IL-10) is widely known as an immunosuppressive cytokine by virtue of its
ability to inhibit macrophage-dependent antigen presentation, T-cell proliferation, and Th1 …

We have shown that DNA encoding the anti-apoptotic protein Bcl-xL enhances E7-specific
CD8+ T-cell responses and DNA encoding pro-apoptotic protein caspase-3 suppresses E7 …

ABSTRACT Human papillomavirus type 16 (HPV-16) infects the genital tract and is closely
associated with the development of cervical cancer. HPV-16 initiates infection at the genital …